Identifying therapeutic target genes for diabetic retinopathy using systematic druggable genome-wide Mendelian randomization

被引:0
|
作者
Long Xie [1 ]
Yu Qin Peng [2 ]
Xiang Shen [1 ]
机构
[1] The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha),Department of Orthopedics
[2] Hunan Normal University,Department of Ophthalmology
[3] The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha),undefined
[4] Hunan Normal University,undefined
来源
关键词
Diabetic retinopathy; Mendelian randomization; GWAS; Druggable target genes;
D O I
10.1186/s13098-025-01710-y
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Mitochondria-Related Genome-Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases
    Wang, Zheyi
    Sun, Yize
    Bai, Zetai
    Li, Mei
    Kong, Deyuan
    Wu, Guanzhao
    MOVEMENT DISORDERS, 2025,
  • [32] Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
    Swerdlow, Daniel I.
    Kuchenbaecker, Karoline B.
    Shah, Sonia
    Sofat, Reecha
    Holmes, Michael V.
    White, Jon
    Mindell, Jennifer S.
    Kivimaki, Mika
    Brunner, Eric J.
    Whittaker, John C.
    Casas, Juan P.
    Hingorani, Aroon D.
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2016, 45 (05) : 1600 - 1616
  • [33] Genome-wide Mendelian randomization identifies drugs associated with body height
    Xi, Li
    Cheng, Ruoqian
    Zhang, Miaoying
    Pei, Zhou
    Ye, Jiangfeng
    Zhao, Zhuhui
    TRANSLATIONAL PEDIATRICS, 2024, 13 (11)
  • [34] Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types
    Li, Yanni
    Sundquist, Kristina
    Zhang, Naiqi
    Wang, Xiao
    Sundquist, Jan
    Memon, Ashfaque A.
    EBIOMEDICINE, 2023, 88
  • [35] Statistical methods for Mendelian randomization in genome-wide association studies: A review
    Boehm, Frederick J.
    Zhou, Xiang
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 20 : 2338 - 2351
  • [36] Systematic genome-wide Mendelian randomization reveals the causal links between miRNAs and Parkinson's disease
    Shi, Guolin
    Wu, Tingting
    Li, Xuetao
    Zhao, Debin
    Yin, Qiuyuan
    Zhu, Lei
    FRONTIERS IN NEUROSCIENCE, 2024, 18
  • [37] Identification of therapeutic targets for chronic kidney disease through Mendelian randomization analysis of druggable genes
    Liang, Run-Sen
    Su, Jin-Qi
    Wu, Xiang-Qi
    Wang, Qi
    Cai, Yong-Mei
    Su, Hong-Yong
    Tang, Ji-Xin
    Yao, Cui-Wei
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [38] Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond
    Walker, Venexia M.
    Zheng, Jie
    Gaunt, Tom R.
    Smith, George Davey
    ANNUAL REVIEW OF BIOMEDICAL DATA SCIENCE, 2022, 5 : 1 - 17
  • [39] Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
    Morrison, Jean
    Knoblauch, Nicholas
    Marcus, Joseph H.
    Stephens, Matthew
    He, Xin
    NATURE GENETICS, 2020, 52 (07) : 740 - +
  • [40] Identifying potential drug targets for idiopathic pulmonary fibrosis: a mendelian randomization study based on the druggable genes
    Liu, Zetao
    Peng, Zhiyu
    Lin, Huahang
    Zhou, Ke
    Liang, Linchuan
    Cao, Jie
    Huang, Zhaokang
    Mei, Jiandong
    RESPIRATORY RESEARCH, 2024, 25 (01)