Chemical-based epigenetic reprogramming to advance pluripotency and totipotency

被引:0
|
作者
Shanshan Wen [1 ]
Ran Zheng [2 ]
Cheguo Cai [2 ]
Wei Jiang [1 ]
机构
[1] Wuhan University,Department of Biological Repositories, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Zhongnan Hospital of Wuhan University
[2] Shenzhen Beike Biotechnology Co.,undefined
[3] Ltd,undefined
[4] Hubei Provincial Key Laboratory of Developmentally Originated Disease,undefined
关键词
D O I
10.1038/s41589-025-01874-8
中图分类号
学科分类号
摘要
Reprogramming technology, breaking the inherent limitations of cellular identity and turning somatic cells into pluripotent cells with more developmental potential, holds great promise for cell therapy and regenerative medicine. Compared with traditional methods based on overexpressing transcription factors, chemical reprogramming with small molecules exhibits substantial advantages in safety and convenience, thus being the leading edge. Over the past decade, a notable focus has been reshaping cellular pluripotency and totipotency using pure small-molecule systems. Here, we provide a concise Review comparing the chemical approaches that have emerged to date and discussing the epigenetic regulatory mechanisms involved in chemical reprogramming. This Review highlights the remarkable potential of small-molecule potions to reformulate cell fate through epigenetic reprogramming and newly discovered actions. We aim to offer insights into chemically controlled cell manipulation and key challenges and future application prospects of chemical reprogramming.
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页码:635 / 647
页数:12
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