Treg cells augment self-tolerance during infectionAutoimmunity

被引：0
|
作者：
Ryoji Kawakami [1 ]
Shimon Sakaguchi [1 ]
机构：
[1] Kyoto University,Department of Experimental Immunology, Institute for Life and Medical Sciences
[2] Osaka University,Department of Experimental Immunology, Immunology Frontier Research Center
来源：
Nature Immunology | 2025年 / 26卷 / 5期
关键词：
D O I：
10.1038/s41590-025-02141-7
中图分类号：
学科分类号：
摘要：
A fine balance is needed for Treg cells to enable immune responses to pathogens without triggering autoimmunity. Data now show that thymus-derived self-peptide-specific Treg cells suppress conventional T cells during infection, but enable immune responses to pathogen-derived peptides, thus promoting self–nonself discrimination.
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页码：650 / 652
页数：2
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