Iron-Photocatalyzed Decarboxylative Alkylation of Carboxylic Acids with Morita-Baylis-Hillman Acetates

被引：0

作者：

Yin, Yanli ^{[1
,2
]}

Chen, Fang ^{[1
]}

Chen, Dong ^{[3
]}

Xie, Peizhong ^{[4
]}

Wang, Dongping ^{[1
]}

Loh, Teck-Peng ^{[1
]}

机构：

[1] Henan Univ Technol, Coll Adv Interdisciplinary Sci & Technol CAIST, Zhengzhou 450001, Henan, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Pingyuan Lab, Xinxiang 453007, Henan, Peoples R China

[3] Henan Univ Engn, Coll Mat Engn, Henan Int Joint Lab Rare Earth Composite Mat, Zhengzhou 450001, Henan, Peoples R China

[4] Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 27卷 / 01期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

PHOTOREDOX CATALYSIS; COUPLING REACTIONS; LIGHT; ALKENES; DERIVATIVES; ARYLATION; AMINES; LIGAND;

D O I：

10.1021/acs.orglett.4c04267

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present an iron-photocatalyzed decarboxylative alkylation strategy involving carboxylic acids and Morita-Baylis-Hillman (MBH) acetates to synthesize E-type tri- and tetrasubstituted alkenes with moderate to excellent stereoselectivity (E/Z ratio up to >19:1). This method is applicable to a broad range of structurally diverse primary, secondary, and tertiary alkyl carboxylic acids, as well as complex pharmaceutical and natural carboxylic acids, achieving efficient alkylation of various MBH acetates under mild conditions (>60 examples, with yields up to 96%). This approach offers a powerful strategy for streamlined alkylation.

引用

页码：269 / 274

页数：6

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