Copper-Catalyzed Cycloaddition/Coupling Cascades of Azomethine Imines with Alkynes for Divergent Synthesis of (Z)-Alkenyl and Alkynyl N,N′-Bicyclic Pyrazolidinones

被引：1

作者：

Jiang, Wei ^{[1
]}

Sun, Bo-Xun ^{[1
]}

Fan, Tai-Gang ^{[1
]}

Zhang, Cui ^{[1
]}

Zhou, Xin-Song ^{[1
]}

Shen, Yuehai ^{[1
]}

Li, Ya-Min ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 51期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; ANTIBACTERIAL AGENTS; CLICK CHEMISTRY; METAL; ALKENES; AMINES; SERIES; AZIDES;

D O I：

10.1021/acs.orglett.4c03824

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed cycloaddition/coupling cascades utilizing azomethine imines and alkynes have been developed for the divergent synthesis of (Z)-alkenyl and alkynyl N,N '-bicyclic pyrazolidinones by varying the reaction conditions. The choice of inert or oxidative atmosphere plays a crucial role in determining the transformation pathways. These reactions have broad substrate scopes and mild conditions, making them potentially useful.

引用

页码：11090 / 11095

页数：6

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