Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma

被引：0
|
作者：
Salagean, Alex-Adrian [1 ]
Moldovan, Cezara-Anca-Denisa [2 ]
Slevin, Mark [3 ]
机构：
[1] George Emil Palade Univ Med Pharm Sci & Technol Ta, Dept Histol, Targu Mures 540142, Romania
[2] George Emil Palade Univ Med Pharm Sci & Technol Ta, Sch Med, Targu Mures 540142, Romania
[3] George Emil Palade Univ Med Pharm Sci & Technol Ta, Ctr Adv Med & Pharmaceut Res, Targu Mures 540142, Romania
来源：
GELS | 2025年 / 11卷 / 01期
关键词：
naked mole-rat; hyaluronan; glioblastoma; targeted drug delivery; CANCER RESISTANCE; SPINAL-CORD; ACID; RECEPTOR; TRANSPLANTATION; ASTROCYTE; CARTILAGE; STROKE; CELLS; TSG-6;
D O I：
10.3390/gels11010050
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
HA (hyaluronan) has been considered in recent years as a naturally occurring modifiable gel-like scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a potential chemotherapeutic delivery agent. Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA-originally identified as a mechanism for maintaining longevity in the naked mole-rat-as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. The unique properties of this unique form of HA cross-linked gel indicate potential future use in the prevention and treatment of both proliferative-based and inflammation-driven disease.
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页数：13
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