Iridium-Catalyzed Chemo- and Enantioselective Hydrogenation of Cycloalkenones to Access Chiral Cycloallylalcohols

被引：0

作者：

Chang, Kedi ^{[1
]}

Yang, Li ^{[1
]}

Liu, Yue ^{[1
]}

Cao, Jinghao ^{[1
]}

Zuo, Linhong ^{[1
]}

Liu, Qixing ^{[1
]}

Zhang, Xumu ^{[2
,3
]}

Yin, Congcong ^{[1
]}

Zhou, Haifeng ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Res Ctr Green Pharmaceut Technol & Proc, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

[3] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 46期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC HYDROGENATION; ALLYLIC ALCOHOLS; KETONES; ENONES; REARRANGEMENT; LIGANDS; AMINES; ALPHA;

D O I：

10.1021/acs.orglett.4c03615

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the efficient synthesis of chiral cycloallylalcohols has been developed, achieving excellent yields and enantioselectivities (>99% conversion, turnover number of <= 50 000, and >99% ee). This approach accommodates a variety of cycloalkenones with different aryl substituents and is tolerant of a broad range of functional groups. The synthetic utility of this method has been demonstrated through gram-scale synthesis and subsequent transformations into diverse enantioenriched oxygen-containing compounds.

引用

页码：9841 / 9846

页数：6

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