Advances in Bacterial Cellulose Production: A Scoping Review

The versatility, contribution to sustainability, and diversity of applications of bacterial cellulose require large-scale production processes and new alternatives in terms of biological systems that, under controlled conditions, favor the growth and production of this biomaterial. This review article describes the technologies developed and the advances achieved in regard to the production of bacterial cellulose on a small and large scale, according to the findings evidenced in the scientific literature in the last ten years. A review, based on the guidelines in the PRISMA (R) methodology, of a selection of articles was carried out, with a Cohen's Kappa coefficient of 0.465; scientific databases, such as Web of Science, SCOPUS, PubMed, Taylor and Francis, and ProQuest, were considered. There is a wide variety of bacterial pulp production systems and the design of such a system is based on the type of cellulose-producing bacteria, oxygen requirements, mixing and agitation, temperature control, sterilization and cleaning requirements, and production scalability. The evolution in the development of bioreactors for bacterial cellulose has focused on improving the production process's efficiency, productivity, and control, and adapting to the specific needs of bacterial strains and industrial applications.