Toward effective oxytocin interventions in autism: Overcoming challenges and harnessing opportunities

被引:1
|
作者
Ricchiuti, Grazia [1 ,2 ]
Tuerlinckx, Elise [1 ,2 ]
Taillieu, Aymara [1 ,2 ]
Prinsen, Jellina [1 ,2 ]
Steyaert, Jean [2 ,3 ,4 ]
Boets, Bart [2 ,3 ]
Alaerts, Kaat [1 ,2 ]
机构
[1] Katholieke Univ Leuven, Dept Rehabil Sci, Neuromodulat Lab, Leuven, Belgium
[2] Katholieke Univ Leuven, Leuven Autism Res LAuRes, Leuven, Belgium
[3] Katholieke Univ Leuven, Ctr Dev Psychiat, Dept Neurosci, Leuven, Belgium
[4] UPC KU Leuven, Dept Child Psychiat, Leuven, Belgium
关键词
Oxytocin; autism; clinical trials; INTRANASAL OXYTOCIN; SPECTRUM DISORDERS; RECEPTOR; METAANALYSIS; BEHAVIORS; CHILDREN; HUMANS;
D O I
10.1177/02698811241309621
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Intranasal administration of oxytocin is emerging as a potential pharmacological option for mitigating social difficulties and regulating stress in autism spectrum disorder. However, initial single-dose and multiple-dose trials showed mixed results, with some demonstrating improvements in social and repetitive behavior and others showing no benefit over placebo. This perspective aims to elucidate factors contributing to this variability and to highlight pitfalls and opportunities in the field. We identified two major factors: design-related elements and individual participant characteristics. Pertaining to design-related elements, optimal dosing regimens have yet to be established, but appear to favor moderate intervention durations (i.e., 4-6 weeks) with intermittent and intermediate dosing (i.e., 24-32 IU every other day). Also, the context of the intervention seems crucial, as enhanced outcomes are mainly observed when oxytocin administration is paired with a socially stimulating and supporting environment. In addition, more adequate outcome measures have to be established to effectively assess oxytocin's impact, including behavioral scales and objective biophysiological markers tapping into stress and neurophysiological regulation. Future research should also account for individual participant differences in biological sex, developmental stage and cognitive and adaptive functioning, and incorporate (epi)genetic screening to identify responders. Overall, refining study designs and personalizing intervention protocols are essential for optimizing oxytocin's prosocial and anxiolytic effect in autism.
引用
收藏
页码:179 / 186
页数:8
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