[1] Nottingham Univ Hosp NHS Trust, Stroke, Nottingham, England
[2] Univ Nottingham, Sch Med, Stroke Trials Unit, Mental Hlth & Clin Neurosci, Nottingham, England
[3] Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland
[4] Univ Nottingham, Sch Med, Mental Hlth & Clin Neurosci, Radiol Sci, Nottingham, England
[5] Univ Hosp Derby & Burton NHS Fdn Trust, Derby Stroke Ctr, Derby, England
[6] Nottingham Univ Hosp NHS Trust, Dept Anaesthesia & Crit Care, Nottingham, England
[7] Univ Aberdeen, Inst Med Sci, Dept Med & Therapeut, Aberdeen, Scotland
[8] Keele Univ, Sch Med, Keele, England