Cu(I)-Catalyzed Highly Regioselective C-H Amidation of Quinoline N-Oxides with Dioxazolones

被引：1

作者：

Ren, Zhiqiang ^{[1
]}

Feng, Tianhui ^{[1
]}

Gao, Tianli ^{[1
]}

Han, Bo ^{[1
]}

Guo, Ruili ^{[1
]}

Ma, Haojie ^{[1
]}

Wang, Ji-Jiang ^{[1
]}

Zhang, Yuqi ^{[1
]}

机构：

[1] Yanan Univ, Coll Chem & Chem Engn, Shaanxi Key Lab Chem React Engn, Lab New Energy & New Funct Mat, Yanan 716000, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 40期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED DIRECT; AMINATION; HYDROAMIDATION;

D O I：

10.1021/acs.orglett.4c03118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Cu(I)-catalyzed highly regioselective synthesis of 2-acetamidequinoline N-oxides using dioxazolones with quinoline N-oxides has been reported. The reaction possesses mild reaction conditions and excellent functional group compatibility. Furthermore, the addition of hydrochloric acid promotes the decomposition of copper complexes, which is beneficial for postprocessing.

引用

页码：8532 / 8536

页数：5

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