Metal-Free Direct Synthesis of N-Sulfonyl Amidines from Thioamides and Electron Deficient N-Sulfonylamides

被引：0

作者：

Vankar, Jigarkumar K. ^{[1
]}

Tothadi, Srinu ^{[2
]}

Gururaja, Guddeangadi N. ^{[1
]}

机构：

[1] Cent Univ Gujarat, Sch Chem Sci, Gandhinagar 382030, India

[2] CSIR Cent Salt & MarineChem Res Inst, Bhavnagar 364002, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 45期

关键词：

ROTATIONAL BARRIER; COUPLING REACTION; 3-COMPONENT; AZIDES; INTERCEPTION; ALKYNE; SALTS;

D O I：

10.1002/ejoc.202400776

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free, efficient synthesis of N-sulfonyl amidines has been demonstrated from easily accessible thioamides and electron-deficient sulfonyl amides. The amidation reaction is facile at room temperature with low sulfonyl amide loading. The reaction with thioamides is illustrated with various thioamides and electron-deficient sulfonyl amides with broad substrate scope. The utility of N-sulfonyl amidine synthesis is validated with late-stage drug functionalization.

引用

页数：6

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