Supramolecular Systems Chemistry Based on the Interplay Between Peptides and Porphyrins

The functions of living organisms are emergent from networks of biomolecules. In this review, we discuss the creation of synthetic life-like systems based on the interplay of peptides and porphyrins in the supramolecular chemical systems. In particular, we focus on the spatiotemporal control of self-assembly processes, which allows for the development of hierarchical structures for biomimetic catalysis and adaptive dynamics for stimulus-responsive structural transformations. Notably, when operating in a nonequilibrium regime-characterized by kinetic traps, feedback loops, and dissipative conditions-the structural landscape expands and system-level properties emerge, including transient catalysis, metabolic self-replication, and Darwinian-like evolution. Controlling these systems at the biointerface would facilitate intelligent therapeutic interventions in the anti-tumor phototherapy. Supramolecular systems chemistry provides a valuable framework for exploring new physicochemical spaces of peptides and porphyrins, and may offer distinct advantages and extensive applications across diverse fields.