Genome-wide identification of Tegillarca granosa ATP-binding cassette (ABC) transporter family related to arsenic toxicity

被引:0
|
作者
Kim, Jinmu [1 ,2 ]
Kim, Hyeon Jin [3 ]
Choi, Eunkyung [1 ]
Park, Jung Jun [4 ]
Cho, Minjoo [1 ]
Choi, Soyun [1 ]
Kim, Hyejin [5 ]
Lee, Jung Sick [3 ]
Park, Hyun [1 ]
机构
[1] Korea Univ, Coll Life Sci & Biotechnol, Div Biotechnol, Seoul 02841, South Korea
[2] Univ Illinois, Dept Evolut Ecol & Behav, Urbana, IL 61801 USA
[3] Chonnam Natl Univ, Dept Aqualife Med, Yeosu 59626, South Korea
[4] Natl Inst Fisheries Sci, East Sea Fisheries Res Inst, Aquaculture Ind Res Div, Kangnung 25435, South Korea
[5] Natl Inst Fisheries Sci, Fisheries Seed & Breeding Res Inst, Haenam 59002, South Korea
关键词
Arsenic; DEGs; Tegillarca granosa; ABC transporters; ABCA3; GENE FAMILY; AQUATIC INVERTEBRATES; HEAVY-METALS; RESISTANCE; EXPOSURE; EXPRESSION; PROTEIN;
D O I
10.1016/j.ygeno.2025.111024
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Arsenic is a widespread environmental contaminant recognized for its high mobility and potential toxicity. Arsenic levels at Suncheon Bay, one of the primary Tegillarca granosa culturation sites in South Korea, were identified as higher than the habitat's threshold effect level (TEL). After 12 and 48 h of arsenic exposure, a total of 939 and 842 DEGs were identified in the gill and mantle, respectively. Detoxification genes were identified based on DEG analysis, and out of 10 ABCA3 genes in T. granosa, seven ABCA3 genes in total were up- and/or downregulated in two tissues. The metabolic and the cell adhesion molecules KEGG pathways were the most enriched among the commonly identified up- and downregulated genes. The 'metabolic process' gene ontology term was highly enriched with upregulated DEGs. We then identified 74 ATP-binding cassette (ABC) genes in the T. granosa genome, which has seven subfamilies (A to G), with gene expansion found in the ABCC and ABCA subfamilies. Although the precise mechanisms of arsenic-induced gene dysregulation remain unknown, our findings suggest that ABCA3 genes might participate in arsenic active transport and play an important role in arsenic detoxification.
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页数:12
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