Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology consensus review on diagnosis, management, and future directions

被引：0

作者：

Lim-Fat, Mary Jane ^{[1
]}

Bennett, Julie ^{[2
,3
]}

Ostrom, Quinn ^{[4
,5
]}

Touat, Mehdi ^{[6
,7
]}

Franceschi, Enrico ^{[8
]}

Schulte, Jessica ^{[9
]}

Bindra, Ranjit S. ^{[10
]}

Fangusaro, Jason ^{[11
]}

Dhall, Girish ^{[12
]}

Nicholson, James ^{[13
]}

Jackson, Sadhana ^{[14
]}

Davidson, Tom Belle ^{[15
]}

Calaminus, Gabriele ^{[16
]}

Robinson, Giles ^{[17
]}

Whittle, James R. ^{[18
,19
,20
]}

Hau, Peter ^{[21
]}

Ramaswamy, Vijay ^{[2
]}

Pajtler, Kristian W. ^{[22
,23
,24
]}

Ruda, Roberta ^{[25
]}

Foreman, Nicholas K. ^{[26
]}

Hervey-Jumper, Shawn L. ^{[27
]}

Das, Sunit ^{[28
]}

Dirks, Peter ^{[29
]}

Bi, Wenya Linda ^{[30
]}

Huang, Annie ^{[2
]}

Merchant, Thomas E. ^{[31
]}

Fouladi, Maryam ^{[32
]}

Aldape, Kenneth ^{[33
]}

van den Bent, Martin J. ^{[34
]}

Packer, Roger J. ^{[35
]}

Miller, Julie J. ^{[36
]}

Reardon, David A. ^{[37
]}

Chang, Susan M. ^{[38
]}

Haas-Kogan, Daphne ^{[39
]}

Tabori, Uri ^{[2
]}

Hawkins, Cynthia ^{[40
]}

Monje, Michelle ^{[41
,42
]}

Wen, Patrick Y. ^{[37
]}

Bouffet, Eric ^{[2
]}

Yeo, Kee Kiat ^{[43
]}

机构：

[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med, Div Neurol, Toronto, ON, Canada

[2] Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada

[3] Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada

[4] Duke Univ, Preston Robert Tisch Brain Tumor Ctr, Sch Med, Durham, NC USA

[5] Cent Brain Tumor Registry United States, Hinsdale, IL USA

[6] Sorbonne Univ, Hop Univ La Pitie Salpetrie Charles Foix, Inst Cerveau, Serv Neurooncol,Inserm,CNRS,UMR S 1127,ICM,AP HP, Paris, France

[7] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

[8] IRCCS Ist Sci Neurolog Bologna, Nervous Syst Med Oncol Dept, Bologna, Italy

[9] Univ Calif San Diego, Dept Neurosci, La Jolla, CA USA

[10] Yale Sch Med, Dept Therapeut Radiol, New Haven, CT USA

[11] Emory Univ, Aflac Canc Ctr, Childrens Healthcare Atlanta, Atlanta, GA USA

[12] Childrens Hosp Los Angeles, Dept Hematol Oncol, Los Angeles, CA USA

[13] Univ Cambridge, Addenbrookes Hosp, Dept Paediat, Cambridge CB2 2QQ, England

[14] Natl Inst Neurol Disorders & Stroke, Surg Neurol Branch, Bethesda, MD USA

[15] Univ Southern Calif, Childrens Hosp Angeles, Canc & Blood Dis Inst, Keck Sch Med, Los Angeles, CA USA

[16] Univ Hosp Bonn, Paediat Haematol & Oncol, Bonn, Germany

[17] St Jude Childrens Res Hosp, Neurobiol & Brain Tumor Program, Dept Oncol, Memphis, TN USA

[18] Peter MacCallum Canc Ctr, Dept Med Oncol, Melbourne, Vic, Australia

[19] WEHI, Personalised Oncol Div, Parkville, Vic, Australia

[20] Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia

[21] Regensburg Univ Hosp, Wilhelm Sander NeuroOncol Unit, Regensburg, Germany

[22] Hopp Childrens Canc Ctr Heidelberg KiTZ, Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[23] German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany

[24] Univ Heidelberg Hosp, Dept Pediat Oncol Hematol & Immunol, Heidelberg, Germany

[25] Univ Turin & City Hlth, Sci Univ Hosp, Dept Neurosci Levi Montalcini R, Div Neurooncol, Turin, Italy

[26] Childrens Hosp Colorado, Ctr Canc & Blood Disorders, Aurora, CO USA

[27] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA USA

[28] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Div Neurosurg, Toronto, ON, Canada

[29] Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada

[30] Brigham & Womens Hosp, Dept Neurosurg, Boston, MA USA

[31] St Jude Childrens Res Hosp, Dept Radiat Oncol, Memphis, TN USA

[32] Univ Cincinnati, Med Ctr, Cincinnati Childrens Hosp, Div Hematol Oncol, Cincinnati, OH 45267 USA

[33] NCI, Lab Pathol, Bethesda, MD USA

[34] Erasmus MC Canc Inst, Brain Tumor Ctr, Rotterdam, Netherlands

[35] Childrens Natl Hosp, Ctr Neurosci & Behav Med, Brain Tumor Inst, Gilbert Family Neurofibromatosis Inst, Washington, DC USA

[36] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Neurooncol, Dept Neurol, Boston, MA 02115 USA

[37] Harvard Med Sch, Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02115 USA

[38] Univ Calif San Francisco, Dept Neurol Surg, Div Neurooncol, San Francisco, CA USA

[39] Harvard Med Sch, Brigham & Womens Hosp, Boston Childrens Hosp, Dana Farber Canc Inst, Boston, MA USA

[40] Hosp Sick Children, Dept Pathol, Toronto, ON, Canada

[41] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[42] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[43] Dana Farber Boston Childrens Canc & Blood Disorder, Dept Pediat Oncol, Boston, MA USA

来源：

NEURO-ONCOLOGY | 2024年

关键词：

adolescents and young adults; brain tumors; precision medicine; survivorship; GERM-CELL TUMORS; LOW-GRADE GLIOMA; DABRAFENIB PLUS TRAMETINIB; PEDIATRIC HIGH-GRADE; PHASE-II TRIAL; RADIATION-THERAPY; VINCRISTINE CHEMOTHERAPY; INCIDENCE PATTERNS; SURVIVAL BENEFIT; EPENDYMAL TUMORS;

D O I：

10.1093/neuonc/noae186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adolescents and young adults (AYAs; ages 15-39 years) are a vulnerable population facing challenges in oncological care, including access to specialized care, transition of care, unique tumor biology, and poor representation in clinical trials. Brain tumors are the second most common tumor type in AYA, with malignant brain tumors being the most common cause of cancer-related death. The 2021 WHO Classification for central nervous system (CNS) Tumors highlights the importance of integrated molecular characterization with histologic diagnosis in several tumors relevant to the AYA population. In this position paper from the Society for Neuro-Oncology (SNO), the diagnosis and management of CNS tumors in AYA is reviewed, focusing on the most common tumor types in this population, namely glioma, medulloblastoma, ependymoma, and CNS germ cell tumor. Current challenges and future directions specific to AYA are also highlighted. Finally, possible solutions to address barriers in the care of AYA patients are discussed, emphasizing the need for multidisciplinary and collaborative approaches that span the pediatric and adult paradigms of care, and incorporating advanced molecular testing, targeted therapy, and AYA-centered care.

引用

页数：20

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