Effect of bariatric surgery on mitochondrial remodeling in human skeletal muscle: a narrative review

被引:1
|
作者
Ge, Xiaochuan [1 ,2 ]
Wang, Zhe [3 ,4 ]
Song, Yafeng [1 ,2 ]
Meng, Hua [3 ,4 ]
机构
[1] Beijing Sport Univ, Dept Exercise Physiol, Beijing, Peoples R China
[2] Beijing Sport Univ, Minist Educ, Key Lab Sports & Phys Fitness, Beijing, Peoples R China
[3] China Japan Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China
[4] China Japan Friendship Hosp, Obes & Metab Dis Ctr, Beijing, Peoples R China
来源
基金
中国国家自然科学基金; 北京市自然科学基金;
关键词
obesity; type; 2; diabetes; weight-loss surgery; skeletal muscle mitochondria; metabolism; GASTRIC BYPASS-SURGERY; WEIGHT-LOSS; INSULIN SENSITIVITY; UNCOUPLING PROTEIN; GLUCOSE-METABOLISM; MEDICAL THERAPY; OBESE WOMEN; RESPIRATION; GENE; RESISTANCE;
D O I
10.3389/fendo.2024.1488715
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In the context of obesity epidemic as a major global public health challenge, bariatric surgery stands out for its significant and long-lasting effectiveness in addressing severe obesity and its associated comorbidities. Skeletal muscle mitochondrial function, which is crucial for maintaining metabolic health, tends to deteriorate with obesity. This review summarized current evidence on the effects of bariatric surgery on skeletal muscle mitochondrial function, with a focus on mitochondrial content, mitochondrial dynamics, mitochondrial respiration and mitochondrial markers in glucolipid metabolism. In conclusion, bariatric surgery impacts skeletal muscle through pathways related to mitochondrial function and induces mitochondrial remodeling in skeletal muscle in various aspects. Future studies should focus on standardized methodologies, larger sample sizes, and better control of confounding factors to further clarify the role of mitochondrial remodeling in the therapeutic benefits of bariatric surgery.
引用
收藏
页数:16
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