A Sterically Tuned 2-Fluoropyridinium Salt for the Catalyst-Free, Visible-Light-Mediated Deoxygenation of Alcohols via an Electron Donor-Acceptor Complex

被引：0
|
作者：
Nanjo, Takeshi [1 ]
Lin, Yixuan [1 ]
Fujii, Yusei [1 ]
Takemoto, Yoshiji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan
来源：
ORGANIC LETTERS | 2025年
关键词：
ARYLATION; REDUCTION; OXALATES;
D O I：
10.1021/acs.orglett.5c00266
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We here report the use of a sterically tuned 2-fluoro-1-methylpyridinium salt for the catalyst-free, visible-light-mediated deoxygenative transformation of alcohols through alkoxypyridinium intermediates. The key to this process is the introduction of a bulky cyclohexyl group at the 3-position of the pyridinium ring, which enforces a favorable conformation for C-O bond cleavage and the formation of an electron donor-acceptor complex between the pyridinium ring and amines.
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页数：6
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