A Sterically Tuned 2-Fluoropyridinium Salt for the Catalyst-Free, Visible-Light-Mediated Deoxygenation of Alcohols via an Electron Donor-Acceptor Complex

被引：0

作者：

Nanjo, Takeshi ^{[1
]}

Lin, Yixuan ^{[1
]}

Fujii, Yusei ^{[1
]}

Takemoto, Yoshiji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2025年

关键词：

ARYLATION; REDUCTION; OXALATES;

D O I：

10.1021/acs.orglett.5c00266

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We here report the use of a sterically tuned 2-fluoro-1-methylpyridinium salt for the catalyst-free, visible-light-mediated deoxygenative transformation of alcohols through alkoxypyridinium intermediates. The key to this process is the introduction of a bulky cyclohexyl group at the 3-position of the pyridinium ring, which enforces a favorable conformation for C-O bond cleavage and the formation of an electron donor-acceptor complex between the pyridinium ring and amines.

引用

页数：6

共 48 条

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