Ceftaroline versus vancomycin for methicillin-resistant Staphylococcus aureus bacteraemia, a matched cohort study
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作者:
Bitterman, Roni
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Rambam Hlth care Campus, Div Infect Dis, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Bitterman, Roni
[1
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Awwad, Aya
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机构:
Technion Israeli Inst Technol, Fac Med, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Awwad, Aya
[2
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Darawsha, Basel
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机构:
Technion Israeli Inst Technol, Fac Med, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Darawsha, Basel
[2
]
Dallashi, Hajar
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机构:
Rambam Hlth Care Campus, Internal Med B, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Dallashi, Hajar
[3
]
Dishon-Benattar, Yael
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机构:
Rambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Univ Haifa, Cheryl Spencer Dept Nursing, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Dishon-Benattar, Yael
[1
,4
]
Pollack, Dina
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机构:
Rambam Hlth care Campus, Microbiol Lab, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Pollack, Dina
[5
]
Paul, Mical
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Rambam Hlth care Campus, Div Infect Dis, Haifa, IsraelRambam Hlth care Campus, Div Infect Dis, Haifa, Israel
Paul, Mical
[1
]
机构:
[1] Rambam Hlth care Campus, Div Infect Dis, Haifa, Israel
[2] Technion Israeli Inst Technol, Fac Med, Haifa, Israel
[3] Rambam Hlth Care Campus, Internal Med B, Haifa, Israel
[4] Univ Haifa, Cheryl Spencer Dept Nursing, Haifa, Israel
[5] Rambam Hlth care Campus, Microbiol Lab, Haifa, Israel
Background: Vancomycin remains the treatment-of-choice in MRSA bacteraemia (MRSAB) despite significant limitations. Objective: To compare the effectiveness of ceftaroline and vancomycin monotherapy as the initial targeted therapy for MRSAB. Methods: We conducted a retrospective matched cohort study. Consecutive adult patients treated with ceftaroline in the years 2019-2021 were matched in a 1:2 ratio with patients who received vancomycin. Controls were matched for performance of trans-oesophageal echocardiography, Charlson comorbidity index and age. The primary outcome was a composite of treatment failure, defined as 90-day mortality or microbiological failure. Descriptive statistics were used to compare the ceftaroline and vancomycin-treated groups. Univariate and multivariable binary logistic regression models were created using ceftaroline treatment as the exposure variable. Results: Forty-five patients treated with ceftaroline for MRSAB were matched with 83 patients who received vancomycin. The groups were well balanced with regards to demographics and clinical characteristics. The primary outcome of treatment failure occurred at a similar rate in patients treated with ceftaroline or vancomycin (51.1%, 23/45% versus 57.8%, 48/83, respectively, P = 0.47). In the multivariable analysis, only age (aOR 1.06, 95% CI 1.01-1.1, P = 0.02) was associated with treatment failure. Acute kidney injury was more common among patients treated with ceftaroline (51.1%, 23/45% versus 18.1%, 15/83, P < 0.001). Conclusions: Ceftaroline was not associated with improved outcomes compared to vancomycin when given as initial treatment for MRSAB, however, it appears to be a viable alternative to vancomycin. Larger studies are needed to provide definitive results and to elucidate the risk of nephrotoxicity.
机构:
Univ Colorado Hosp, Dept Pharm, Aurora, CO USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, 12850 E Montview Blvd, Aurora, CO 80045 USAUniv Colorado Hosp, Dept Pharm, Aurora, CO USA
Johnson, Tanner M.
Molina, Kyle C.
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机构:
Univ Colorado Hosp, Dept Pharm, Aurora, CO USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, 12850 E Montview Blvd, Aurora, CO 80045 USAUniv Colorado Hosp, Dept Pharm, Aurora, CO USA
Molina, Kyle C.
Miller, Matthew A.
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机构:
Univ Colorado Hosp, Dept Pharm, Aurora, CO USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, 12850 E Montview Blvd, Aurora, CO 80045 USAUniv Colorado Hosp, Dept Pharm, Aurora, CO USA
Miller, Matthew A.
Kiser, Tyree H.
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机构:
Univ Colorado Hosp, Dept Pharm, Aurora, CO USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, 12850 E Montview Blvd, Aurora, CO 80045 USAUniv Colorado Hosp, Dept Pharm, Aurora, CO USA
Kiser, Tyree H.
Huang, Misha
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机构:
Univ Colorado Hosp, Dept Med Infect Dis, Aurora, CO USA
Univ Colorado, Sch Med, Div Infect Dis, Aurora, CO USAUniv Colorado Hosp, Dept Pharm, Aurora, CO USA
Huang, Misha
Mueller, Scott W.
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机构:
Univ Colorado Hosp, Dept Pharm, Aurora, CO USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, 12850 E Montview Blvd, Aurora, CO 80045 USAUniv Colorado Hosp, Dept Pharm, Aurora, CO USA
机构:
Massachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA
Cosimi, Reese A.
Beik, Nahal
论文数: 0引用数: 0
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机构:
Brigham & Womens Hosp, Ctr Drug Policy Partners Healthcare, 75 Francis St, Boston, MA 02115 USAMassachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA
Beik, Nahal
Kubiak, David W.
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机构:
Brigham & Womens Hosp, Dept Pharm, 75 Francis St, Boston, MA 02115 USAMassachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA
Kubiak, David W.
Johnson, Jennifer A.
论文数: 0引用数: 0
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机构:
Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA
Harvard Med Sch, Cambridge, MA USAMassachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA
机构:
Univ N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USAUniv N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA
Salerno, Sara N.
Bernhardt, Janice
论文数: 0引用数: 0
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机构:
Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USAUniv N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA
Bernhardt, Janice
Laughon, Matthew
论文数: 0引用数: 0
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机构:
Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USAUniv N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA
Laughon, Matthew
Jhaveri, Ravi
论文数: 0引用数: 0
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机构:
Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USAUniv N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA
Jhaveri, Ravi
Massaro, Matthew
论文数: 0引用数: 0
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机构:
Univ N Carolina, Dept Pediat, Chapel Hill, NC 27599 USAUniv N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA
Massaro, Matthew
Gonzalez, Daniel
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机构:
Univ N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USAUniv N Carolina, UNC Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA
机构:
Sci Res Inst Childrens Infect, St Petersburg, RussiaSci Res Inst Childrens Infect, St Petersburg, Russia
Gostev, V. V.
Kalinogorskaya, O. S.
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机构:
Sci Res Inst Childrens Infect, St Petersburg, RussiaSci Res Inst Childrens Infect, St Petersburg, Russia
Kalinogorskaya, O. S.
Dmitrenko, O. A.
论文数: 0引用数: 0
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机构:
Res Ctr Epidemiol & Microbiol, Moscow, RussiaSci Res Inst Childrens Infect, St Petersburg, Russia
Dmitrenko, O. A.
Tsvetkova, I. A.
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机构:
Sci Res Inst Childrens Infect, St Petersburg, RussiaSci Res Inst Childrens Infect, St Petersburg, Russia
Tsvetkova, I. A.
Sidorenko, S., V
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机构:
Sci Res Inst Childrens Infect, St Petersburg, Russia
North Western State Med Univ, St Petersburg, RussiaSci Res Inst Childrens Infect, St Petersburg, Russia
机构:
Natl Taiwan Univ, Sch Med, Coll Med, Taipei City, TaiwanNatl Taiwan Univ, Sch Med, Coll Med, Taipei City, Taiwan
Tsai, Cheng-En
Yang, Chia-Jui
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机构:
Far Eastern Mem Hosp, Dept Internal Med, New Taipei City, Taiwan
Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, TaiwanNatl Taiwan Univ, Sch Med, Coll Med, Taipei City, Taiwan