Detection of high levels of mutant huntingtin protein in tear fluid of patients with Huntington's Disease

被引:0
|
作者
Gijs, Marlies [1 ]
Jorna, Nynke [2 ]
Datson, Nicole [3 ]
Beekman, Chantal [3 ]
Dansokho, Cira [4 ]
Weiss, Alexander [4 ]
Linden, David [2 ]
Oosterloo, Mayke [2 ]
机构
[1] Univ Maastricht, Univ Eye Clin Maastricht, Maastricht, Netherlands
[2] Univ Maastricht, Neurol, Maastricht, Netherlands
[3] VICO Therapeut, Leiden, Netherlands
[4] Evotec SE, Hamburg, Germany
关键词
D O I
暂无
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
3322
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Mutant Huntingtin Derails Cysteine Metabolism in Huntington's Disease at Both Transcriptional and Post-Translational Levels
    Paul, Bindu D.
    Sbodio, Juan I.
    Snyder, Solomon H.
    ANTIOXIDANTS, 2022, 11 (08)
  • [32] Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington's Disease
    Osmand, Alexander P.
    Bichell, Terry Jo.
    Bowman, Aaron B.
    Bates, Gillian P.
    JOURNAL OF HUNTINGTONS DISEASE, 2016, 5 (04) : 343 - 346
  • [33] Analysis of mutant and total huntingtin expression in Huntington's disease murine models
    Fodale, Valentina
    Pintauro, Roberta
    Daldin, Manuel
    Altobelli, Roberta
    Spiezia, Maria Carolina
    Bisbocci, Monica
    Macdonald, Douglas
    Bresciani, Alberto
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [34] The roles of Huntingtin Associated Protein 40 in Huntingtin functions and Huntington's disease pathogenesis
    Xu, S.
    Li, G.
    Ye, X.
    Ye, L.
    Xu, Z.
    Stimming, E. Furr
    Zhang, S.
    MOVEMENT DISORDERS, 2020, 35 : S104 - S104
  • [35] Quantification of Mutant Huntingtin Protein (mHTT) in Human Cerebrospinal Fluid to Support Clinical Development of mHTT-Targeting Therapies in Huntington's Disease
    Schutz, Katharina
    Buehler, Alessandra
    Schick, Eginhard
    Young, Marianne Manchester
    Boak, Lauren
    Schobel, Scott A.
    Hawellek, David J.
    NEUROTHERAPEUTICS, 2020, 17 (SUPPL 1) : 23 - 24
  • [36] Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy
    Mas-Monteys, Alex
    Harper, Scott Q.
    Gilmore, Brian L.
    Staber, Patrick D.
    Schaffer, Chris
    Polisky, Barry
    Vargeese, Chandra
    Davidson, Beverly L.
    MOLECULAR THERAPY, 2006, 13 : S274 - S275
  • [37] VALIDATION OF SUPPRESSORS OF MUTANT HUNTINGTIN TOXICITY IN A FLY MODEL OF HUNTINGTON'S DISEASE
    Casu, M.
    Campesan, S.
    Clapp, J.
    Kyriacou, C. P.
    Giorgini, F.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 : A11 - A11
  • [38] Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease
    Rodrigues, Filipe B.
    Byrne, Lauren M.
    Johnson, Eileanoir
    Wijeratne, Peter
    de Vita, Enrico
    Alexander, Daniel
    Palermo, Giuseppe
    Czech, Christian
    Schobel, Scott
    Scahill, Rachael
    Heslegrave, Amanda
    Zetterberg, Henrik
    Wild, Edward
    NEUROLOGY, 2019, 92 (15)
  • [39] Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression
    Weiss, Andreas
    Traeger, Ulrike
    Wild, Edward J.
    Grueninger, Stephan
    Farmer, Ruth
    Landles, Christian
    Scahil, Rachael I.
    Lahiri, Nayana
    Haider, Salman
    Macdonald, Douglas
    Frost, Chris
    Bates, Gillian P.
    Bilbe, Graeme
    Kuhn, Rainer
    Andre, Ralph
    Tabrizi, Sarah J.
    JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (10): : 3731 - 3736
  • [40] Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression
    Wild, E. J.
    Weiss, A.
    Trager, U.
    Grueninger, S.
    Farmer, R.
    Landles, C.
    Scahill, R.
    Lahiri, N.
    Haider, S.
    Macdonald, D.
    Frost, C.
    Bates, G.
    Bilbe, G.
    Kuhn, R.
    Andre, R.
    Tabrizi, S.
    MOVEMENT DISORDERS, 2013, 28 : S268 - S269