The role of the sulfaguanidine molecular scaffold in drug design and development

Developing new molecular entities is one of the most emerging research areas in the field of Medicinal Chemistry. Over the past few years, rigorous research has been conducted on sulfaguanidine-linked synthetic molecules because of their promising potential in several biological activities. Sulfaguanidine has been actively incorporated in the design of anticancer, antimicrobial, antidiabetic, antiparkinsonian, anti-inflammatory, and antiviral candidates. The construction of these effective candidates has adopted many chemical approaches. A number of the prepared compounds displayed promising results that merit further investigations for the development of new medications. This review summarizes the different chemical strategies and the reported activities for sulfaguanidine-linked synthetic molecules throughout 2020-2024.