First-line (1L) zolbetuximab plus chemotherapy in patients (pts) with claudin 18.2 (CLDN18.2) +, HER2-, locally advanced (LA) unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma: A pooled final analysis of SPOTLIGHT plus GLOW

被引:0
|
作者
Kang, Y-K. [1 ]
Shah, M. A. [2 ]
Shitara, K. [3 ]
Ajani, J. A. [4 ]
Lordick, F. [5 ]
Van Cutsem, E. [6 ]
Ilson, D. H. [7 ]
Klempner, S. J. [8 ]
Yamaguchi, K. [9 ]
Nakajima, T. [10 ]
Cao, Y. J. [11 ]
Li, R. [12 ]
Moran, D. [11 ]
Pophale, R. R. [13 ]
Ranganath, R. [13 ]
Xu, R-H. [14 ]
机构
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Oncol Dept, Seoul, South Korea
[2] Weill Cornell Med Coll, Med Oncol & Hematol Dept, New York, NY USA
[3] Natl Canc Ctr Hosp East, Dept Gastrointestinal Oncol, Kashiwa, Chiba, Japan
[4] Univ Texas MD Anderson Canc Ctr, GI Med Oncol, Houston, TX USA
[5] Univ Krebszentrum Leipzig, Univ Klinikum Leipzig, Med Dept, Leipzig, Germany
[6] UZ Leuven, Univ Hosp Leuven, Digest Oncol Dept, Campus Gasthuisberg, Leuven, Belgium
[7] Mem Sloan Kettering Evelyn H Lauder Breast Ctr, Dept Med, New York, NY USA
[8] MGH Massachusetts Gen Hosp, Dept Med Oncol, Boston, MA USA
[9] Canc Inst Hosp JFCR, Gastroenterol Chemotherapy Dept, Koto Ku, Tokyo, Japan
[10] Astellas Pharma Global Dev, Med Dept, Northbrook, IL USA
[11] Astellas Pharma Global Dev Inc, Data Sci, Northbrook, IL USA
[12] Astellas Pharma Global Dev, Data Sci, Northbrook, IL USA
[13] Astellas Pharma Global Dev Inc, Med Affairs Dept, Northbrook, IL USA
[14] Sun Yat Sen Univ Canc Ctr, Dept Med Oncol, Guangzhou, Peoples R China
关键词
D O I
10.1016/j.annonc.2024.08.1504
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1438P
引用
收藏
页码:S895 / S895
页数:1
相关论文
共 50 条
  • [41] A randomized phase II clinical trial evaluating the safety and efficacy of initial dose adjustment of zolbetuximab plus chemotherapy in patients with HER2-negative and CLDN18.2-positive unresectable advanced or recurrent gastric, gastroesophageal junction cancer or esophageal adenocarcinoma (GENTLE-Z).
    Okunaka, Mashiro
    Furuoka, Momoka
    Wakabayashi, Masashi
    Furuya, Hideki
    Bando, Hideaki
    Shitara, Kohei
    Nakayama, Izuma
    JOURNAL OF CLINICAL ONCOLOGY, 2025, 43 (4_SUPPL) : TPS504 - TPS504
  • [42] Health-related quality of life (hrqol) analysis from KEYNOTE-859: First-line (1L) pembrolizumab (pembro) plus chemotherapy (chemo) for advanced HER2-negative gastric or gastroesophageal junction (G/GEJ) adenocarcinoma
    Lowery, M.
    Wyrwicz, L.
    Oh, D-Y.
    Shiu, K. K.
    Weber, P. Yanez
    Bai, Y.
    Lee, J.
    Rivera, F.
    Alves, G.
    Garrido, M.
    Fernandez, M. Gonzalez
    Li, J.
    Cil, T.
    Cruz, F.
    Qin, S.
    Yin, L.
    Valderrama, A.
    Bordia, S.
    Rha, S. Y.
    ANNALS OF ONCOLOGY, 2023, 34 : S854 - S855
  • [43] Zolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial (vol 401, pg 1655, 2023)
    Shitara, K.
    Lordick, F.
    Bang, Y-J
    LANCET, 2023, 402 (10398): : 290 - 290
  • [44] A phase 2 study (DisTinGuish) of DKN-01 in combination with tislelizumab plus chemotherapy as first-line (1L) therapy in patients with advanced gastric or GEJ adenocarcinoma (GEA)
    Klempner, Samuel J.
    Sonbol, Bassam Bassam
    Wainberg, Zev A.
    Uronis, Hope Elizabeth
    Chiu, Vi Kien
    Scott, Aaron James
    Iqbal, Syma
    Tejani, Mohamedtaki Abdulaziz
    Stilian, Melissa C.
    Thoma, Mathis
    Kagey, Michael
    Baum, Jason
    Sirard, Cynthia A.
    Altura, Rachel A.
    Ajani, Jaffer A.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [45] Tislelizumab (TIS) plus chemotherapy (Chemo) vs placebo (PBO) plus chemo as first-line (1L) treatment of advanced gastric or gastroesophageal junction adenocarcinoma (GC/GEJC): Final analysis results of the RATIONALE-305 study
    Xu, R-H.
    Oh, D-Y.
    Kato, K.
    Arkenau, T.
    Tabernero, J.
    Cruz-Correa, M.
    Zimina, A.
    Bai, Y.
    Shi, J.
    Lee, K-W.
    Hirano, H.
    Spigel, D. R.
    Wyrwicz, L. S.
    Cid, R. A. Pazo
    Li, L.
    Xu, Y.
    McHenry, M. B.
    Yang, S.
    Moehler, M.
    ANNALS OF ONCOLOGY, 2023, 34 : S1320 - S1321
  • [46] Tislelizumab (TIS) plus chemotherapy (Chemo) vs placebo (PBO) plus chemo as first-line (1L) treatment of advanced gastric or gastroesophageal junction adenocarcinoma (GC/GEJC): Final analysis results of the RATIONALE-305 study
    Xu, R-H.
    Oh, D-Y.
    Kato, K.
    Arkenau, H-T.
    Tabernero, J.
    Cruz-Correa, M.
    Zimina, A. V.
    Bai, Y.
    Shi, J.
    Lee, K-W.
    Hirano, H.
    Spigel, D. R.
    Wyrwicz, L. S.
    Pazo Cid, R. A.
    Li, L.
    Xu, Y.
    McHenry, M. B.
    Yang, S.
    Moehler, M.
    ANNALS OF ONCOLOGY, 2023, 34 : S1526 - S1527
  • [47] Number needed to treat (NNT) analysis of patients in CheckMate 649 (CM 649): Nivolumab plus chemotherapy versus chemotherapy as first-line (1L) treatment for advanced gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC/GEJ/EAC)
    Sugarman, Ryan
    Nunna, Sasikiran
    Betts, Keith A.
    Nie, Xiaoyu
    Nguyen, Hiep
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (04)
  • [48] First-line (1L) fuzuloparib plus mfolfirinox followed by maintenance fuzuloparib in patients (pts) with unresectable locally advanced or metastatic (LA/M) pancreatic cancer (PC): A phase Ib study
    Yu, X.
    Mou, Y.
    Chen, X.
    Liu, C.
    Zhang, X.
    Xu, J.
    Zhang, J.
    Shi, S.
    Wei, M.
    Li, J.
    Liu, R.
    Gao, S.
    Xu, L.
    Sheng, Z.
    Lian, J.
    Shi, Q.
    ANNALS OF ONCOLOGY, 2023, 34 : S901 - S902
  • [49] Cost-effectiveness analysis of nivolumab plus standard chemotherapy versus chemotherapy alone for the first-line treatment of unresectable advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma
    Jiang, Yuan
    Li, Yue
    Wang, Larry X. W.
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 2022, 44 (02) : 499 - 506
  • [50] Cost-effectiveness analysis of nivolumab plus standard chemotherapy versus chemotherapy alone for the first-line treatment of unresectable advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma
    Yuan Jiang
    Yue Li
    Larry X. W. Wang
    International Journal of Clinical Pharmacy, 2022, 44 : 499 - 506