Real-World Early Outcomes of Second-Line Axicabtagene Ciloleucel (Axi-Cel) Therapy in Patients (Pts) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL)

被引:0
|
作者
Lee, Dasom [1 ]
Kambhampati, Swetha [2 ]
Bobillo, Maria Silvina Odstrcil [3 ]
Adedokun, Babatunde [4 ]
Shadman, Mazyar [5 ,6 ]
Olson, Amanda L. [7 ]
Herrera, Alex F. [8 ]
Lee, Catherine J. [5 ,6 ]
Jacobson, Caron A. [9 ]
Bye, Matthew [10 ]
Hamadani, Mehdi [10 ]
Kim, Soyoung [11 ]
Dahiya, Saurabh [12 ]
Hu, Zhen-Huan [4 ]
Speth, Kelly [4 ]
To, Christina [4 ]
Mirjah, Debbie L. [13 ]
Best, Timothy [4 ]
Locke, Frederick L. [14 ]
Ahmed, Nausheen [15 ]
Tees, Michael T. [16 ]
Pasquini, Marcelo C. [17 ]
Ahmed, Sairah [18 ]
机构
[1] Stanford Univ, Div Hematol, Palo Alto, CA USA
[2] City Hope Natl Med Ctr, Yorba Linda, CA USA
[3] Univ Utah, Salt Lake City, UT USA
[4] Kite A Gilead Co, Santa Monica, CA USA
[5] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA USA
[6] Med Oncol Div, Seattle, WA USA
[7] Univ Texas MD Anderson Canc Ctr, Houston, TX USA
[8] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA
[9] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA
[10] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res CIBMTR, Milwaukee, WI USA
[11] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Registry CIBMTR, CIBMTR Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI USA
[12] Stanford Univ, Div Hematol, Stanford, CA USA
[13] Gilead Co, Santa Monica, CA USA
[14] H Lee Moffitt Canc Ctr & Res Inst, Blood & Marrow Transplant & Cellular Immunotherapy, Tampa, FL USA
[15] Univ Kansas, Div Hematol Malignancies & Cellular Therapeut, Med Ctr, Kansas City, KS USA
[16] Sarah Cannon transplant & Cellular Therapy Network, Nashville, TN USA
[17] Dana Farber Canc Inst, Boston, MA USA
[18] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma & Stem Cell Transplantat, Houston, TX USA
关键词
D O I
10.1182/blood-2024-199139
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:527 / 528
页数:2
相关论文
共 50 条
  • [41] A Comparison of 2-Year Outcomes in ZUMA-1 (Axicabtagene Ciloleucel; Axi-Cel) and SCHOLAR-1 in Patients (Pts) with Refractory Large B Cell Lymphoma (LBCL)
    Neelapu, Sattva S.
    Locke, Frederick L.
    Bartlett, Nancy L.
    Lekakis, Lazaros J.
    Reagan, Patrick
    Miklos, David B.
    Jacobson, Caron A.
    Braunschweig, Ira
    Oluwole, Olalekan
    Siddiqi, Tanya
    Lin, Yi
    Crump, Michael
    Kuruvilla, John
    Van den Neste, Erin
    Farooq, Umar
    Navale, Lynn
    DePuy, Venita
    Kim, Jenny
    Gisselbrecht, Christian
    MOLECULAR THERAPY, 2020, 28 (04) : 575 - 576
  • [42] Outcomes of Subsequent Anti-Lymphoma Therapies in Patients (Pts) with Large B-Cell Lymphoma (LBCL) Treated with Axicabtagene Ciloleucel (Axi-Cel) or Standard of Care (SOC) in the Second-Line (2L) ZUMA-7 Study
    Ghobadi, Armin
    Munoz, Javier
    Westin, Jason
    Locke, Frederick L.
    Miklos, David B.
    Rapoport, Aaron P.
    Perales, Miguel-Angel
    Reagan, Patrick M.
    McGuirk, Joseph P.
    Jacobson, Caron A.
    Kersten, Marie Jose
    Avivi, Irit
    Peng, Andrew
    Schupp, Marco
    To, Christina
    Oluwole, Olalekan O.
    BLOOD, 2022, 140 : 1595 - 1597
  • [43] Outcomes of Patients (Pts) in ZUMA-9, a Multicenter, Open-Label Study of Axicabtagene Ciloleucel (Axi-Cel) in Relapsed/Refractory Large B Cell Lymphoma (R/R LBCL) for Expanded Access and Commercial Out-of-Specification (OOS) Product
    Jacobson, Caron A.
    Locke, Frederick L.
    Miklos, David B.
    Vose, Julie M.
    Lin, Yi
    Budde, Lihua E.
    Maloney, David G.
    Jaglowski, Samantha
    Riedell, Peter A.
    Lekakis, Lazaros J.
    Perales, Miguel-Angel
    Kim, Jenny J.
    Kawashima, Jun
    Yang, Yin
    Rossi, John M.
    Goyal, Lovely
    Neelapu, Sattva S.
    BLOOD, 2020, 136
  • [44] Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma
    Locke, F. L.
    Miklos, D. B.
    Jacobson, C. A.
    Perales, M-A
    Kersten, M-J
    Oluwole, O. O.
    Ghobadi, A.
    Rapoport, A. P.
    McGuirk, J.
    Pagel, J. M.
    Munoz, J.
    Farooq, U.
    van Meerten, T.
    Reagan, P. M.
    Sureda, A.
    Flinn, I. W.
    Vandenberghe, P.
    Song, K. W.
    Dickinson, M.
    Minnema, M. C.
    Riedell, P. A.
    Leslie, L. A.
    Chaganti, S.
    Yang, Y.
    Filosto, S.
    Shah, J.
    Schupp, M.
    To, C.
    Cheng, P.
    Gordon, L., I
    Westin, J. R.
    NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (07): : 640 - 654
  • [45] Prophylactic Corticosteroid Use with Axicabtagene Ciloleucel (Axi-Cel) in Patients (Pts) with Relapsed/ Refractory Large B-Cell Lymphoma (R/R LBCL): One-Year Follow-up of ZUMA-1 Cohort 6 (C6)
    Oluwole, Olalekan O.
    Forcade, Edouard
    Muñoz, Javier
    de Guibert, Sophie
    Vose, Julie M.
    Bartlett, Nancy L.
    Lin, Yi
    Deol, Abhinav
    McSweeney, Peter A.
    Goy, Andre H.
    Kersten, Marie Jose
    Jacobson, Caron
    Farooq, Umar
    Minnema, Monique C.
    Thieblemont, Catherine
    Timmerman, John M.
    Stiff, Patrick
    Avivi, Irit
    Tzachanis, Dimitrios
    Kim, Jenny J.
    Zheng, Yan
    Shen, Rhine R.
    Vardhanabhuti, Saran
    Van Meerten, Tom
    BLOOD, 2021, 138
  • [46] Real-world outcomes of patients with relapsed/refractory large B-cell lymphoma receiving second-line therapy in England
    Fox, Christopher P.
    Townsend, William
    Gribben, John G.
    Menne, Tobias
    Kalakonda, Nagesh
    Williams, Paula
    Toron, Farah
    Tyas, Emma
    Cooper, Miranda
    Rickards, Joshua
    Radford, John
    EJHAEM, 2024, 5 (05): : 992 - 997
  • [47] Updated outcomes with axicabtagene ciloleucel (axi-cel) retreatment (reTx) in patients (pts) with relapsed/refractory (R/R) indolent non-Hodgkin lymphoma (iNHL) in ZUMA-5.
    Chavez, Julio C.
    Jacobson, Caron A.
    Sehgal, Alison
    Neelapu, Sattva Swarup
    Maloney, David G.
    Salles, Gilles A.
    William, Basem M.
    Yang, Yin
    Goyal, Lovely
    Chou, Justin
    Plaks, Vicki
    Avanzi, Mauro P.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [48] Axicabtagene ciloleucel (axi-cel) in combination with rituximab (Rtx) for the treatment (Tx) of refractory large B-cell lymphoma (R-LBCL): Outcomes of the phase 2 ZUMA-14 study.
    Strati, Paolo
    Leslie, Lori Ann
    Shiraz, Parveen
    Budde, L. Elizabeth
    Oluwole, Olalekan O.
    Ulrickson, Matthew
    Ramakrishnan, Aravind
    Sun, Jennifer
    Shen, Rhine
    Kanska, Justyna
    McCroskery, Peter
    Dong, Jinghui
    Schupp, Marco Andreas
    Xu, Hairong
    Patel, Krish
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [49] Axicabtagene Ciloleucel (Axi-cel) CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma: Real World Experience
    Nastoupil, Loretta J.
    Jain, Michael D.
    Spiegel, Jay Y.
    Ghobadi, Armin
    Lin, Yi
    Dahiya, Saurabh
    Lunning, Matthew A.
    Lekakis, Lazaros J.
    Reagan, Patrick M.
    Oluwole, Olalekan O.
    McGuirk, Joseph P.
    Deol, Abhinav
    Sehgal, Alison R.
    Goy, Andre
    Hill, Brian T.
    Andreadis, Charalambos
    Munoz, Javier
    Westin, Jason R.
    Chavez, Julio C.
    Cashen, Amanda F.
    Bennani, Nora N.
    Rapoport, Aaron P.
    Vose, Julie M.
    Miklos, David B.
    Neelapu, Sattva S.
    Locke, Frederick L.
    BLOOD, 2018, 132
  • [50] ZUMA-12: A phase 2 multicenter study of axicabtagene ciloleucel (axi-cel) as a first-line therapy in patients (pts) with high-risk large B-cell lymphoma (LBCL).
    Neelapu, Sattva Swarup
    Chavez, Julio C.
    Lin, Yi
    Munoz, Javier
    Ujjani, Chaitra Shankar
    Riedell, Peter
    De Vos, Sven
    Oluwole, Olalekan O.
    Kekre, Natasha
    Yang, Yin
    Goyal, Lovely
    Backhouse, Kate
    Milletti, Francesca
    Kawashima, Jun
    Herrera, Alex Francisco
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)