Catalytic Asymmetric 1,4-Hydrocarbonation of 1,3-Enynes via Photoredox/Cobalt/Chromium Triple Catalysis

被引：0

作者：

Yang, Ju-Song ^{[1
]}

Wang, Xing-Yu ^{[2
]}

Li, Yong-Yao ^{[2
]}

Zhang, Fu-Min ^{[2
]}

Zhang, Xiao-Ming ^{[2
]}

Tu, Yong-Qiang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Chiral Drugs & Engn, Frontier Sci Ctr Transformat Mol, Shanghai Minhang 200240, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2025年 / 64卷 / 09期

基金：

国家重点研发计划;

关键词：

1,4-hydrocarbonation; 1,3-enynes; central and axial chirality; photoredox/cobalt/chromium triple catalysis; mechanism investigation;

D O I：

10.1002/anie.202420563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synergistic photoredox/cobalt/chromium triple catalysis system for regioselective, enantioselective, and diastereoselective 1,4-hydrocarbonation of readily available 1,3-enyne precursors was explored, providing a modular synthetic platform for various trisubstituted axially chiral allenes bearing an extra central chirality. The protocol features a broad substrate scope, good functional group tolerance, excellent selectivity, and mild reaction conditions. Furthermore, a possible reaction mechanism is proposed based on numerous control experiments and density functional theory calculations.

引用

页数：10

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