How can trial designs better serve the needs of children and young people with juvenile idiopathic arthritis?

被引：3

作者：

Feilding, Freya Luling ^{[1
]}

Crosby, Laura ^{[6
]}

Earle, Emily ^{[2
,3
]}

Beesley, Richard ^{[2
,4
]}

Leslie, Kerry ^{[2
]}

MacDonald, Eilean ^{[2
]}

Wright, Catherine ^{[2
,5
]}

Wilson, Debbie ^{[2
]}

Sherriffs, Anna ^{[2
]}

Duerr, Teresa ^{[6
]}

Ramanan, Athimalaipet, V ^{[6
,7
]}

机构：

[1] UCL Great Ormond St Inst Child Hlth, Infect Immun & Inflammat Res & Teaching Dept, London, England

[2] UCL Great Ormond St Inst Child Hlth, CLUSTER Consortium Champ, London, England

[3] Childrens Chron Arthrit Assoc, Nuneaton, England

[4] Juvenile Arthrit Res, Tonbridge, England

[5] Versus Arthrit, Chesterfield, England

[6] Bristol Royal Hosp Children, Dept Paediat Rheumatol, Bristol BS2 8AE, England

[7] Univ Bristol, Translat Hlth Sci, Bristol, England

来源：

LANCET RHEUMATOLOGY | 2024年 / 6卷 / 09期

基金：

英国医学研究理事会;

关键词：

METHOTREXATE;

D O I：

10.1016/S2665-9913(24)00026-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In juvenile idiopathic arthritis we have seen remarkable progress in the number of available licensed biological and small molecule treatments in the past two decades, leading to improved outcomes for patients. Designing clinical trials for these therapeutics is fraught with ethical, legislative, and practical challenges. However, many aspects of current clinical trial design in juvenile idiopathic arthritis do not meet the needs of patients and clinicians. Commonly used withdrawal trial designs raise substantial ethical concerns for patients and families who believe that they do not enable evidence-based and patient-centred decisions around medication choices. In this Viewpoint, we present the personal views of a patient and parent network that is of the opinion that current trial design in juvenile idiopathic arthritis is failing children and young people with juvenile idiopathic arthritis and set out the need for change informed by lived experience.

引用

页数：5

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