Distress and Its Determinants in 820 Consecutive Melanoma Patients

Background: Psycho-oncological burden not only affects patients' mental health but can also decrease treatment compliance and impair outcomes. The Distress Thermometer (DT) is a widely used screening tool in real-world medical care for identifying and monitoring psychological distress. Patients with melanoma presenting in oncologic outpatient departments comprise a wide range of characteristics. Although young adults may face challenges related to pivotal life stages, such as career responsibilities or parenting, older adults often contend with mobility issues, preexisting comorbidities, or age-related physical limitations. Methods: We conducted a retrospective evaluation of DT data from 820 patients with melanoma treated at our outpatient department between July and September 2016. These patients underwent routine DT screening and completed the associated National Comprehensive Cancer Network (NCCN) Problem List. The study aimed to identify factors influencing DT values above the threshold (>= 5), further characterizing the patients' complaints according to the NCCN Problem List. Results: A total of 820 patients with melanoma underwent psycho-oncological screening. More than 40% had DT values above the threshold. Significant factors associated with DT values over the threshold included female gender, younger age, and advanced melanoma stages III-IV. Analysis of the NCCN Problem List revealed complaints such as fear, sleep issues, tingling in hands and feet, feeling swollen, problems at work or school, concerns regarding God, and loss of faith. Conclusion: The results indicate a high need for psycho-oncological support for patients with melanoma. Particular attention should be given to patients with the identified factors that are associated with exceeding the DT threshold.