Elevated hematopoietic stem cell frequency in mouse alveolar bone marrow

被引:1
|
作者
Niizuma, Kouta [1 ,2 ]
Morikawa, Satoru [1 ,2 ,7 ]
Gars, Eric [1 ]
Xiang, Jinyi [1 ,4 ]
Matsubara-Takahashi, Tomoko [8 ]
Saito, Rei [8 ]
Takematsu, Eri [1 ,3 ]
Wang, Yuting [1 ,3 ]
Xu, Haojun [5 ]
Wakimoto, Arata [11 ]
Tan, Tze Kai [1 ,2 ]
Kubota, Yoshiaki [8 ]
Chan, Charles K. F. [1 ,3 ]
Weissman, Irving L. [1 ,4 ]
Nakagawa, Taneaki [7 ]
Wilkinson, Adam C. [1 ,2 ,9 ]
Nakauchi, Hiromitsu [1 ,2 ,6 ]
Yamamoto, Ryo [1 ,2 ,10 ]
机构
[1] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[5] Stanford Univ, Dept Neurol, Sch Med, Stanford, CA 94305 USA
[6] Univ Tokyo, Inst Med Sci, Div Stem Cell Therapy, Distinguished Prof Unit, Tokyo, Japan
[7] Keio Univ, Sch Med, Dept Dent & Oral Surg, Tokyo, Japan
[8] Keio Univ, Sch Med, Dept Anat, Tokyo, Japan
[9] Univ Oxford, MRC Weatherall Inst Mol Med, Radcliffe Dept Med, Oxford, England
[10] Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Kyoto 6068501, Japan
[11] Univ Tsukuba, Sch Integrat & Global Majors, Program Human Biol, Ibaraki 3058575, Japan
来源
STEM CELL REPORTS | 2025年 / 20卷 / 01期
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.stemcr.2024.11.004
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Hematopoietic stem cells (HSCs) are crucial for maintaining hematopoietic homeostasis and are localized within distinct bone marrow (BM) niches. While BM niches are often considered similar across different skeletal sites, we discovered that the alveolar BM (al-BM) in the mandible harbors the highest frequency of immunophenotypic HSCs in nine different skeletal sites. Transplantation assays revealed significantly increased engraftment from al-BM compared to femur, tibia, or pelvis BM, likely due to a higher proportion of alveolar HSCs. Moreover, hematopoietic progenitor cells (c-Kit+Sca-1+ Lin-) in al-BM exhibited increased quiescence and reduced apoptosis, indicating superior maintenance and survival characteristics. We also observed an enrichment of mesenchymal stromal cells and skeletal stem cells in al-BM, suggesting a more supportive microenvironment. These findings indicate that al-BM provides a unique microenvironment conducive to higher frequency of HSCs, offering new insights into site-specific hematopoiesis.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Glial cell regulation of hematopoietic stem cell hibernation in the bone marrow niche
    Nakauchi, Hiromitsu
    HUMAN GENE THERAPY, 2012, 23 (10) : A27 - A27
  • [22] Bone marrow Schwann cells induce hematopoietic stem cell hibernation
    Yamazaki, Satoshi
    Nakauchi, Hiromitsu
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2014, 99 (06) : 695 - 698
  • [23] Hematopoietic stem cell stretches and moves in its bone marrow niche
    Silva, Walison N.
    Costa, Alinne C.
    Picoli, Caroline C.
    Rocha, Beatriz G. S.
    Santos, Gabryella S. P.
    Costa, Pedro A. C.
    Azimnasab-sorkhabi, Parviz
    Soltani-asl, Maryam
    Silva, Rodrigo A. da
    Amorim, Jaime Henrique
    Resende, Rodrigo R.
    Mintz, Akiva
    Birbrair, Alexander
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2021, 163
  • [24] Role of neuropeptide Y in the bone marrow hematopoietic stem cell microenvironment
    Park, Min Hee
    Min, Woo-Kie
    Jin, Hee Kyung
    Bae, Jae-sung
    BMB REPORTS, 2015, 48 (12) : 645 - 646
  • [25] Hematopoietic stem cell engraftment in bone marrow is dependent upon Gsα.
    Adams, Gregor B.
    Alley, Ian R.
    Chabner, Karissa T.
    Chung, Ung-il
    Marsters, Emily S.
    Weinstein, Lee S.
    Kronenberg, Henry M.
    Scadden, David T.
    BLOOD, 2006, 108 (11) : 257A - 257A
  • [26] Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche
    Cuminetti, Vincent
    Arranz, Lorena
    JOURNAL OF CLINICAL MEDICINE, 2019, 8 (05)
  • [27] Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
    Mansour, Anna
    Abou-Ezzi, Grazia
    Sitnicka, Ewa
    Jacobsen, Sten Eirik W.
    Wakkach, Abdelilah
    Blin-Wakkach, Claudine
    JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (03): : 537 - 549
  • [28] Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity
    Rimmele, Pauline
    Lofek-Czubek, Sebastien
    Ghaffari, Saghi
    AMERICAN JOURNAL OF HEMATOLOGY, 2014, 89 (12) : E235 - E238
  • [29] Bone Marrow GvHD after Allogeneic Hematopoietic Stem Cell Transplantation
    Szyska, Martin
    Na, Il-Kang
    FRONTIERS IN IMMUNOLOGY, 2016, 7
  • [30] Hepatic thrombopoietin is required for bone marrow hematopoietic stem cell maintenance
    Decker, Matthew
    Leslie, Juliana
    Liu, Qingxue
    Ding, Lei
    SCIENCE, 2018, 360 (6384) : 106 - 110