Oxidized Phospholipids and Calcific Aortic Valvular Disease

被引:1
|
作者
Bhatia, Harpreet S. [1 ]
Dweck, Marc R. [2 ]
Craig, Neil [2 ]
Capoulade, Romain [3 ]
Pibarot, Philippe [4 ]
Trainor, Patrick J. [5 ]
Whelton, Seamus P. [6 ]
Rikhi, Rishi [7 ]
Lidani, Karita C. F. [8 ]
Post, Wendy S. [6 ]
Tsai, Michael Y. [9 ]
Criqui, Michael H. [10 ]
Shapiro, Michael D. [1 ,7 ]
Budoff, Matthew J. [11 ]
DeFilippis, Andrew P. [8 ]
Thanassoulis, George [12 ]
Tsimikas, Sotirios [1 ]
机构
[1] Univ Calif San Diego, Dept Med, Div Cardiol, La Jolla, CA USA
[2] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Scotland
[3] Nantes Univ, CNRS, INSERM, CHU Nantes,Inst Thorax, Nantes, France
[4] Laval Univ, Inst Univ Cardiol & Pneumol Quebec, Dept Cardiol, Quebec City, PQ, Canada
[5] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM USA
[6] Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD USA
[7] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Sect Cardiovasc Med, Winston Salem, NC USA
[8] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc Med, Nashville, TN USA
[9] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA
[10] Univ Calif San Diego, Dept Family & Prevent Med, Div Family Med, La Jolla, CA 92093 USA
[11] Harbor UCLA Med Ctr, Lundquist Inst, Torrance, CA 90509 USA
[12] McGill Univ, Hlth Ctr, Dept Med, Div Expt Med, Montreal, PQ, Canada
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
aortic valve; calcification; computed tomography; lipoprotein(a); oxidized phospholipids; subclinical atherosclerosis; POSITRON-EMISSION-TOMOGRAPHY; VALVE STENOSIS; PERCUTANEOUS CORONARY; APOLIPOPROTEIN B-100; LIPOPROTEIN(A); PROGRESSION; ATHEROSCLEROSIS; INFLAMMATION; RISK; PROMOTES;
D O I
10.1016/j.jacc.2024.08.070
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND Oxidized phospholipids (OxPLs) are carried by apolipoprotein B-100-containing lipoproteins (OxPL-apoB) including lipoprotein(a) (Lp[a]). Both OxPL-apoB and Lp(a) have been associated with calcific aortic valve disease (CAVD). OBJECTIVES This study aimed to evaluate the associations between OxPL-apoB, Lp(a) and the prevalence, incidence, and progression of CAVD. METHODS OxPL-apoB and Lp(a) were evaluated in MESA (Multi-Ethnic Study of Atherosclerosis) and a participant-level meta-analysis of 4 randomized trials of participants with established aortic stenosis (AS). In MESA, the association of OxPL-apoB and Lp(a) with aortic valve calcium (AVC) at baseline and 9.5 years was evaluated using multivariable ordinal regression models. In the meta-analysis, the association between OxPL-apoB and Lp(a) with AS progression (annualized change in peak aortic valve jet velocity) was evaluated using multivariable linear regression models. RESULTS In MESA, both OxPL-apoB and Lp(a) were associated with prevalent AVC (OR per SD: 1.19 [95% CI: 1.07-1.32] and 1.13 [95% CI: 1.01-1.27], respectively) with a significant interaction between the two (P < 0.01). Both OxPL-apoB and Lp(a) were associated with incident AVC at 9.5 years when evaluated individually (interaction P < 0.01). The OxPL-apoB & lowast;Lp(a) interaction demonstrated higher odds of prevalent and incident AVC for OxPL-apoB with increasing Lp(a) levels. In the meta-analysis, when analyzed separately, both OxPL-apoB and Lp(a) were associated with faster increase in peak aortic valve jet velocity, but when evaluated together, only OxPL-apoB remained significant (ss: 0.07; 95% CI: 0.01-0.12). CONCLUSIONS OxPL-apoB is a predictor of the presence, incidence, and progression of AVC and established AS, particularly in the setting of elevated Lp(a) levels, and may represent a novel therapeutic target for CAVD. (c) 2024 by the American College of Cardiology Foundation.
引用
收藏
页码:2430 / 2441
页数:12
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