The Potential Role of Cigarette Smoke, Elastic Fibers, and Secondary Lung Injury in the Transition of Pulmonary Emphysema to Combined Pulmonary Fibrosis and Emphysema

被引:0
|
作者
Cantor, Jerome [1 ]
机构
[1] St Johns Univ, Sch Pharm & Allied Hlth Sci, Queens, NY 11439 USA
关键词
pulmonary fibrosis; pulmonary emphysema; cigarette smoke; lipopolysaccharide; elastin; desmosine; FREQUENT EXACERBATION; DESMOSINE;
D O I
10.3390/ijms252111793
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Combined pulmonary fibrosis and emphysema (CPFE) is a distinct syndrome associated with heavy smoking. The fibrotic component of the disease is generally believed to be superimposed on previously existing pulmonary emphysema, but the mechanisms responsible for these changes remain poorly understood. To better understand the pathogenesis of CPFE, we performed a series of experiments that focused on the relationships between lung elastic fibers, cigarette smoke, and secondary lung injury. The results indicate that even brief smoke exposure predisposes the lung to additional forms of lung injury that may cause alveolar wall fibrosis. The proinflammatory activity of smoke-induced structural alterations in elastic fibers may contribute to this process by enhancing secondary lung inflammation, including acute exacerbations of chronic obstructive pulmonary disease. Furthermore, the levels of the unique elastin crosslinks, desmosine and isodesmosine, in blood, urine, and sputum may serve as biomarkers for the transition from pulmonary emphysema to interstitial fibrosis. While the long-term effects of these inflammatory reactions were not examined, the current studies provide insight into the potential relationships between elastic fiber injury, cigarette smoke, and secondary lung injury. Determining the mechanisms involved in combined pulmonary emphysema and fibrosis and developing a sensitive biomarker for this type of lung injury may permit timely therapeutic intervention that could mitigate the high risk of respiratory failure associated with this condition.
引用
收藏
页数:14
相关论文
共 50 条
  • [41] Combined Pulmonary Fibrosis and Emphysema Alters Physiology but Has Similar Mortality to Pulmonary Fibrosis Without Emphysema
    Matthew D. Jankowich
    Sharon Rounds
    Lung, 2010, 188 : 365 - 373
  • [42] Comparison of the efficacy of pirfenidone in patients with combined pulmonary fibrosis and emphysema and idiopathic pulmonary fibrosis without emphysema
    Gwon, Hye Ran
    Kim, Song Yee
    Park, Jong Sun
    Park, Moo Suk
    RESPIROLOGY, 2023, 28 : 358 - 358
  • [43] Cigarette smoke inhibits the growth of lung fibroblasts from patients with pulmonary emphysema
    Nobukuni, S
    Watanabe, K
    Inoue, J
    Wen, FQ
    Tamaru, N
    Yoshida, M
    RESPIROLOGY, 2002, 7 (03) : 217 - 223
  • [44] The decline in lung function is related to both emphysema and fibrosis extent in patients with idiopathic pulmonary fibrosis (IPP)/ combined pulmonary fibrosis and emphysema (CPFE)
    Cottin, Vincent
    Hansen, David
    Antoniou, Katerina
    Nair, Arjun
    Atwood, Mark
    Sverzellati, Nicola
    Oster, Gerry
    Weycker, Derek
    Collard, Harold R.
    Wells, Athol
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44
  • [45] Differing Expression of Cytokines and Tumor Markers in Combined Pulmonary Fibrosis and Emphysema Compared to Emphysema and Pulmonary Fibrosis
    Xu, Ling
    Bian, Wei
    Gu, Xiao-hua
    Shen, Ce
    COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2017, 14 (02) : 245 - 250
  • [46] Combined Pulmonary Fibrosis and Emphysema Alters Physiology but Has Similar Mortality to Pulmonary Fibrosis Without Emphysema
    Jankowich, Matthew D.
    Rounds, Sharon
    LUNG, 2010, 188 (05) : 365 - 373
  • [47] Electrocardiogram Signs in Idiopathic Pulmonary Fibrosis and Combined Pulmonary Fibrosis and Emphysema
    Nishimura, M.
    Ohta, S.
    Shinada, K.
    Hirouchi, T.
    Morikawa, M.
    Yamanaka, S.
    Shinoda, M.
    Sasaki, O.
    Shinkai, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [48] Imaging Diagnosis of Interstitial Pneumonia with Emphysema (Combined Pulmonary Fibrosis and Emphysema)
    Sakai, Fumikazu
    Tominaga, Junya
    Kaga, Akiko
    Usui, Yutaka
    Kanazawa, Minoru
    Ogura, Takashi
    Yanagawa, Noriyo
    Takemura, Tamiko
    PULMONARY MEDICINE, 2012, 2012
  • [49] Patterns and Prevalence of Progressive Pulmonary Fibrosis in Combined Pulmonary Fibrosis and Emphysema
    Agwaramgbo, E.
    Mak, K.
    Selvan, K. C.
    Adegunsoye, A. O.
    Strek, M. E.
    Lee, C. T.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [50] A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema
    Athol U. Wells
    Joseph Jacob
    Nicola Sverzellati
    Gary Cross
    Joseph Barnett
    Angelo De Lauretis
    Katerina Antoniou
    Derek Weycker
    Mark Atwood
    Klaus-Uwe Kirchgaessler
    Vincent Cottin
    Respiratory Research, 25