DRP1: shedding light on the complex nexus of mitochondrial fission and breast cancer

被引:0
|
作者
You, Li [1 ]
Wang, Min [1 ]
Liu, Xuexue [1 ]
Song, Miao [1 ]
Zhou, Jiahong [1 ]
Feng, Jia [1 ]
Liu, Jinbo [1 ]
机构
[1] Southwest Med Univ, Affiliated Hosp, Sichuan Prov Engn Technol Res Ctr Mol Diag Clin Di, Dept Lab Med,Mol Diag Clin Dis Key Lab Luzhou, 25 Taiping St, Luzhou 646099, Sichuan, Peoples R China
关键词
Breast cancer; mitochondrial; fission; fusion; DRP1; DYNAMIN-RELATED PROTEIN-1; CELL-DEATH; APOPTOSIS; IDENTIFICATION; FRAGMENTATION; INHIBITORS; MIGRATION;
D O I
10.1080/14796694.2024.2447813
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer (BC) is a global women's health concern, with ongoing research to address diagnostic and treatment challenges. Understanding the developmental mechanisms is vital for improved clinical prevention and treatment strategies. Mitochondria, undergo dynamic processes like fission and fusion, regulated by proteins like Dynamic-related protein 1 (DRP1). DRP1 plays a key role in mitochondrial fission, a process associated with BC development. This study aims to explore the impact of DRP1 on BC growth, assessing its potential as a therapeutic target. The findings could contribute to a better understanding of mitochondria-related molecular mechanisms in BC development and guide the identification of clinical drug targets.
引用
收藏
页码:593 / 603
页数:11
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