DRP1: shedding light on the complex nexus of mitochondrial fission and breast cancer

被引:0
|
作者
You, Li [1 ]
Wang, Min [1 ]
Liu, Xuexue [1 ]
Song, Miao [1 ]
Zhou, Jiahong [1 ]
Feng, Jia [1 ]
Liu, Jinbo [1 ]
机构
[1] Southwest Med Univ, Affiliated Hosp, Sichuan Prov Engn Technol Res Ctr Mol Diag Clin Di, Dept Lab Med,Mol Diag Clin Dis Key Lab Luzhou, 25 Taiping St, Luzhou 646099, Sichuan, Peoples R China
关键词
Breast cancer; mitochondrial; fission; fusion; DRP1; DYNAMIN-RELATED PROTEIN-1; CELL-DEATH; APOPTOSIS; IDENTIFICATION; FRAGMENTATION; INHIBITORS; MIGRATION;
D O I
10.1080/14796694.2024.2447813
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer (BC) is a global women's health concern, with ongoing research to address diagnostic and treatment challenges. Understanding the developmental mechanisms is vital for improved clinical prevention and treatment strategies. Mitochondria, undergo dynamic processes like fission and fusion, regulated by proteins like Dynamic-related protein 1 (DRP1). DRP1 plays a key role in mitochondrial fission, a process associated with BC development. This study aims to explore the impact of DRP1 on BC growth, assessing its potential as a therapeutic target. The findings could contribute to a better understanding of mitochondria-related molecular mechanisms in BC development and guide the identification of clinical drug targets.
引用
收藏
页码:593 / 603
页数:11
相关论文
共 50 条
  • [1] Recruitment of Drp1 in Mitochondrial Fission
    Egner, John M.
    Bakkum, Amber
    Gardner, Alex
    Hill, Blake
    FASEB JOURNAL, 2017, 31
  • [2] Mitochondrial fission requires DRP1 but not dynamins
    Fonseca, Tiago Branco
    Sanchez-Guerrero, Angela
    Milosevic, Ira
    Raimundo, Nuno
    NATURE, 2019, 570 (7761) : E34 - E42
  • [3] Mitochondrial fission requires DRP1 but not dynamins
    Tiago Branco Fonseca
    Ángela Sánchez-Guerrero
    Ira Milosevic
    Nuno Raimundo
    Nature, 2019, 570 : E34 - E42
  • [4] Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division
    Mears, Jason A.
    Ramachandran, Rajesh
    CURRENT OPINION IN PHYSIOLOGY, 2022, 29
  • [5] Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1
    Santel, Ansgar
    Frank, Stephan
    IUBMB LIFE, 2008, 60 (07) : 448 - 455
  • [6] RhoA Regulation of Drp1 and Cardiac Mitochondrial Fission
    Brand, Cameron S.
    Tan-Sah, Valerie P.
    Brown, Joan Heller
    Miyamoto, Shigeki
    FASEB JOURNAL, 2016, 30
  • [7] Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
    Simula, Luca
    Campanella, Michelangelo
    Campello, Silvia
    PHARMACOLOGICAL RESEARCH, 2019, 146
  • [8] Mitochondrial Fission Protein Drp1 Regulates Platelet Function
    Jacob, Shancy
    Tistao, Marina
    Gomez, Abigail Ajanel
    Denorme, Frederik
    Kosaka, Yasuhiro
    Manne, Bhanu Kanth
    Guo, Li
    Campbell, Robert A.
    Rondina, Matthew T.
    Rowley, Jesse W.
    BLOOD, 2023, 142
  • [9] DRP1, fission and apoptosis
    Nan Wang
    Xinwai Wang
    Beiwu Lan
    Yufei Gao
    Yuanyuan Cai
    Cell Death Discovery, 11 (1)
  • [10] A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis
    Tanaka, Atsushi
    Youle, Richard J.
    MOLECULAR CELL, 2008, 29 (04) : 409 - 410