Circulating Extracellular Vesicles: An Effective Biomarker for Cancer Progression

被引:1
|
作者
Chatterjee, Madhura [1 ]
Gupta, Saurabh [2 ]
Nag, Sayoni [3 ]
Rehman, Ishita [4 ]
Parashar, Deepak [5 ]
Maitra, Arindam [1 ]
Das, Kaushik [1 ]
机构
[1] Natl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
[2] GLA Univ, Dept Biotechnol, Mathura 281406, India
[3] Brainware Univ, Dept Biotechnol, Barasat 700125, India
[4] Neotia Univ, Dept Biotechnol, Parganas 743368, India
[5] Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2024年 / 29卷 / 11期
关键词
biomarkers; cancer biomarkers; circulating extracellular vesicles; clinical trials; extracellular vesicles; therapeutics; POTENTIAL DIAGNOSTIC BIOMARKERS; EXOSOME-MEDIATED TRANSFER; INTERCELLULAR COMMUNICATION; CELLS PROMOTES; MESSENGER-RNA; PROGNOSTIC BIOMARKER; SERUM EXOSOMES; MICROVESICLES; EXPRESSION; MECHANISM;
D O I
10.31083/j.fbl2911375
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extracellular vesicles (EVs), the ubiquitous part of human biology, represent a small heterogenous, membrane-enclosed body that contains a diverse payload including genetic materials in the form of DNA, RNAs, small non-coding RNAs, etc. mostly mirroring their source of origin. Since, a vast majority of research has been conducted on how nucleic acids, proteins, lipids, and metabolites, associated with EVs can be effectively utilized to identify disease progression and therapeutic responses in cancer patients, EVs are increasingly being touted as valuable and reliable identifiers of cancer biomarkers in liquid biopsies. However, the lack of comprehensive clinical validation and effective standardization protocols severely limits its applications beyond the laboratories. The present review focuses on understanding the role of circulating EVs in different cancers and how they could potentially be treated as cancer biomarkers, typically due to the presence of bioactive molecules such as small non-coding RNAs, RNAs, DNA, proteins, etc., and their utilization for fine-tuning therapies. Here, we provide a brief general biology of EVs including their classification and subsequently discuss the source of circulatory EVs, the role of their associated payload as biomarkers, and how different cancers affect the level of circulatory EVs population.
引用
收藏
页数:22
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