Independent and Combined Associations between Metals Exposure and Inflammatory Markers among the General US Adults

被引:0
|
作者
Feng, Xinrui [1 ]
Luo, Yaoyu [1 ]
Zheng, Min [1 ]
Sun, Xiaojie [2 ]
Shen, Xiantao [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth,Minist Environm Protect, State Key Lab Environm Hlth Incubat,Key Lab Enviro, Wuhan 430030, Hubei, Peoples R China
[2] Wuhan Univ Sci & Technol, Sch Publ Hlth, Dept Environm Hyg & Occupat Med, Wuhan 430065, Peoples R China
来源
ENVIRONMENT & HEALTH | 2024年
基金
中国国家自然科学基金;
关键词
Cross-sectional study; Metals exposure; Inflammatorymarkers; NHANES; Weighted quantile sum regression; Quantile g-computation; TO-LYMPHOCYTE RATIO; MEAN PLATELET VOLUME; DISEASE; INTERLEUKIN-6; MONOCYTES; COBALT; PLR; NLR;
D O I
10.1021/envhealth.4c00097
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposure to metals can trigger a series of diseases by dysregulating the human immune system, but there is still a lack of systematic studies assessing the independent and combined effects of exposure to metals on immune function in the general population, particularly concerning inflammation markers. This cross-sectional study was designed to mainly examine the associations between urinary metal mixtures and inflammatory markers, including white blood cell (WBC), platelet count (PLT), mean platelet volume (MPV), MPV/PLT ratio (MPR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR). A total of 3451 participants aged >= 20 years were selected from the 2013-2016 National Health and Nutrition Examination Survey. Generalized linear models were used to investigate the relationships of exposure to single metals on inflammatory markers. Associations between coexposure to multiple metals and inflammatory markers were determined using weighted quantile sum regression and quantile g-computation. Barium, cadmium, lead, thallium, and cobalt showed significant associations with MPV, PLR, and NLR. Metal mixtures showed a negative association with MPV, while they had positive associations with PLR and NLR. Overall, our study highlights the significant effects of multiple metals exposure on inflammation markers, including MPV, PLR, and NLR, among U.S. adults. Thereinto, uranium, cadmium, and cobalt were identified as major contributors. Further prospective studies representative of other countries are warranted to either validate or refute our findings.
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页数:9
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