Convalescent plasma in patients receiving rituximab or ocrelizumab for multiple sclerosis or neuromyelitis Optica spectrum disorder with Covid-19:A multicenter retrospective study

被引：0

作者：

Dequidt, Tanguy ^{[1
]}

Richier, Quentin ^{[2
]}

Louapre, Celine ^{[3
]}

Ader, Florence ^{[4
]}

Merad, Yanis ^{[4
]}

Lauwerier, Nicolas ^{[5
]}

Jacomet, Christine ^{[6
]}

Carles, Michel ^{[7
]}

Biron, Charlotte ^{[8
]}

Gendrin, Vincent ^{[9
]}

Marlat, Clement ^{[10
]}

Danion, Francois ^{[11
]}

Lepage, Tristan M. ^{[12
]}

Sotto, Albert ^{[13
]}

Bourdellon, Loic ^{[14
]}

Mania, Alexandre ^{[15
]}

Martinot, Martin ^{[16
]}

Le Falher, Georges ^{[17
]}

Ferre, Alexis ^{[18
]}

Pilmis, Benoit ^{[19
]}

Gondran, Guillaume ^{[20
]}

Simeone, Pierre ^{[21
]}

Henry, Matthieu ^{[22
]}

Kamel, Toufik ^{[23
]}

Ray, Simon ^{[24
]}

Ancellin, Sophie ^{[25
]}

Mele, Nicolas ^{[26
]}

Camou, Fabrice ^{[27
]}

Destremau, Marjolaine ^{[27
]}

Sellenet, Jeremy ^{[28
]}

Zucman, Noemie ^{[29
]}

Le Marechal, Marion ^{[30
]}

Mellouki, Khawla ^{[31
]}

Langlois, Marie-Elodie ^{[32
]}

Paz, David Luque ^{[33
]}

Mousset, Maud ^{[34
]}

Leclerc, Catherine ^{[35
]}

Sommet, Agnes ^{[36
]}

Lacombe, Karine ^{[37
]}

Martin-Blondel, Guillaume ^{[38
,39
]}

机构：

[1] Guadeloupe Univ Hosp, Dept Infect Dis, Pointe A Pitre, France

[2] Sorbonne Univ, St Antoine Hosp, Dept Infect Dis, AP HP, Paris, France

[3] Sorbonne Univ, Pitie Salpetriere Hosp, Paris Brain Inst, Dept Neurol,AP HP,CIC Neurosci, Paris, France

[4] Hosp Civils Lyon, Dept Infect Dis, Lyon, France

[5] Lille Univ Hosp, Dept Infect Dis, Lille, France

[6] Clermont Ferrand Univ Hosp, Dept Infect Dis, Clermont Ferrand, France

[7] Nice Univ Hosp, Dept Infect Dis, Nice, France

[8] Nantes Univ Hosp, Dept Infect Dis, Nantes, France

[9] Nord Franche Comte Hosp, Dept Infect Dis, Belfort, France

[10] Rouen Univ Hosp, Dept Infect Dis, Rouen, France

[11] Strasbourg Univ Hosp, Dept Infect Dis, Strasbourg, France

[12] Montpellier Univ Hosp, Dept Infect Dis, Montpellier, France

[13] Nimes Univ Hosp, Dept Infect Dis, Nimes, France

[14] Emile Durkheim Hosp, Med Unit A, Epinal, France

[15] Henri Mondor Hosp, Dept Internal Med, Aurillac, France

[16] Colmar Hosp, Dept Infect Dis, Colmar, France

[17] Beziers Hosp, Dept Internal Med, Beziers, France

[18] Versailles Hosp, Intens Care Unit, Le Chesnay, France

[19] Grp Hosp Paris St Joseph, Microbiol Unit, Antimicrobial Stewardship Team, Paris, France

[20] Limoges Univ Hosp, Dept Internal Med, Limoges, France

[21] Univ Hosp Timone, Dept Anesthesiol & Crit Care Med, AP HM, Marseille, France

[22] Dist Hosp Ctr, Med Surg Intens Care Unit, Le Roche Sur Yon, France

[23] Orleans Univ Hosp, Intens Care Unit, Orleans, France

[24] Rodez Hosp, Dept Infect Dis, Rodez, France

[25] Auch Hosp, Dept Infect Dis, Auch, France

[26] Sainte Anne Hosp, Dept Neurol, GHU Paris Psychiat & Neurosci, Paris, France

[27] Bordeaux Univ Hosp, Intens Care & Infect Dis Unit, Grp St Andre, Bordeaux, France

[28] St Jean Sud France Clin, Dept Internal Med, St Jean De Vedas, France

[29] CH Annecy Genevois, Intens Care Unit, Epagny Metz Tessy, France

[30] Univ Grenoble Alpes, Infect Dis Dept, CHU Grenoble Alpes, Grenoble, France

[31] Claude Bernard Univ Lyon 1, Valence Hosp Ctr, Dept Infect Dis, Valence, France

[32] St Joseph St Luc Hosp, Dept Internal Med & Infect Dis, Lyon, France

[33] Pontchaillou Univ Hosp, Infect Dis & Intens Care Unit, Rennes, France

[34] Comminges Pyrenees Hosp, Intens Care Unit, St Gaudens, France

[35] CHI Poissy St Germain En Laye, Dept Infect Dis, St Germain En Laye, France

[36] Toulouse Univ Hosp, Clin Invest Ctr, Toulouse, France

[37] Sorbonne Univ, St Antoine Hosp, Infect Dis Dept, IPLESP Inserm, Paris, France

[38] Toulouse Univ Hosp, Dept Infect Dis, Toulouse, France

[39] Toulouse III Univ, Toulouse Inst Infect & Inflammatory Dis, INSERM UMR1291 CNRS UMR5051, Toulouse, France

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2025年 / 151卷

关键词：

SARS-CoV-2; Protracted COVID-19; Convalescent plasma; Anti-CD20; antibodies; Multiple sclerosis; Neuromyelitis optica; THERAPY;

D O I：

10.1016/j.ijid.2024.107323

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Despite vaccination, patients receiving anti-CD20 monoclonal antibodies (mAbs) for multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD) have an increased risk of developing severe or protracted COVID-19. The aim of this study was to describe the effect of COVID-19 convalescent plasma (CCP) in patients with MS or NMOSD exposed to anti-CD20 and infected by SARS-CoV-2. Methods: This French national, retrospective cohort study was conducted between November 2020 and June 2023. Patients with MS or NMOSD, under anti-CD20 mAbs, with symptomatic COVID-19 and treated by CCP were screened. Protracted COVID-19 was defined by a duration of symptoms > 21 days. The primary endpoint was the overall survival 30 days after CCP administration. Results: Ninety-two patients from 34 hospitals were included, 84 (91%) with MS and 8 (9%) with NMOSD. Overall, 30-day survival was 97% (IC95%: 91-99). SARS-CoV-2 viremia was positive in 47/75 (61%) patients before CCP versus 9/59 (15%) seven days post-CCP. In the 52 patients (57%) with protracted COVID-19, the duration of symptoms before CCP was 51 [28-69] days, including fever in 75% of cases, which disappeared in 100% of patients 7 days post-CCP. Conclusions: CCP could be a therapeutic option in patients exposed to anti-CD20 mAbs for inflammatory demyelinating disease, particularly in those with protracted COVID-19. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

引用

页数：9

共 50 条

[31] Hospital Readmission Rates in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder Patients
Padarti, A.
Amod, A.
Kilgo, W. A.
MULTIPLE SCLEROSIS JOURNAL, 2023, 29 : 64 - 65
[32] Comparison of ocular changes in multiple sclerosis and neuromyelitis optica spectrum disorder patients
Wang, Xiaoyue
Bao, Li
FRONTIERS IN NEUROLOGY, 2024, 15
[33] Sleep in multiple sclerosis and neuromyelitis optica spectrum disorder-the SEMN study
Sousa, Nise Alessandra Carvalho
de Almeida, Carlos Mauricio Oliveira
Takano, Satiko Andrezza Ferreira
Souza, Siane Prado Lima
Rabelo, Ronaldo Marques Pontes
SLEEP AND BREATHING, 2023, 27 (06) : 2453 - 2458
[34] Management Strategies of Patients with Neuromyelitis Optica Spectrum Disorder During the COVID-19 Pandemic Era
Hamdy, Sherif M.
Abdel-Naseer, Maged
Shehata, Hatem S.
Shalaby, Nevin M.
Hassan, Amr
Elmazny, Alaa
Shaker, Ehab
Nada, Mona A. F.
Ahmed, Sandra M.
Hegazy, Mohamed, I
Mourad, Husam S.
Abdelalim, Ahmed
Magdy, Rehab
Othman, Alshimaa S.
Mekkawy, Doaa A.
Kishk, Nirmeen A.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2020, 16 : 759 - 767
[35] Recurrent hiccups in COVID-19 forme fruste of neuromyelitis optica spectrum disorder?
Shubhakaran, Khichar P.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2022, 11 (06) : 3388 - 3388
[36] Therapeutic plasma exchange for neuromyelitis optica spectrum disorder: A multicenter retrospective study by the ASFA neurologic diseases subcommittee
Ipe, Tina S.
Raval, Jay S.
Fernando, Leonor P.
Gokhale, Amit
Jacquot, Cyril
Johnson, Andrew D.
Kim, Haewon C.
Monis, Grace F.
Mo, Yunchun D.
Morgan, Shanna M.
Pagano, Monica B.
Pham, Huy P.
Sanford, Kimberly
Schmidt, Amy E.
Schwartz, Joseph
Waldman, Amy
Webb, Jennifer
Winters, Jeffrey L.
Wu, Yanyun
Yamada, Chisa
Wong, Edward C. C.
JOURNAL OF CLINICAL APHERESIS, 2020, 35 (01) : 25 - 32
[37] Clinical Features of COVID-19 on Patients With Neuromyelitis Optica Spectrum Disorders
Apostolos-Pereira, Samira Luisa
Campos Ferreira, Lis
Boaventura, Mateus
de Carvalho Sousa, Nise Alessandra
Joca Martins, Gabriela
d'Almeida, Jose Arthur
Pitombeira, Milena
Silvestre Mendes, Lucas
Fukuda, Thiago
Souza Cabeca, Hideraldo Luiz
Chaves Rocha, Luciano
Santos de Oliveira, Bianca
Vieira Stella, Carla Renata
Lobato de Oliveira, Enedina Maria
de Souza Amorim, Leizian
Ferrari de Castro, Andrea
Pereira Gomes Neto, Antonio
Diogo Silva, Guilherme
Bueno, Lucas
de Morais Machado, Maria
Castello Dias-Carneiro, Rafael
Maciel Dias, Ronaldo
Porto Moreira, Alvaro
Piccolo, Ana
Kuntz Grzesiuk, Anderson
Muniz, Andre
Diniz Disserol, Caio
Ferreira Vasconcelos, Claudia
Kaimen-Maciel, Damacio
Sisterolli Diniz, Denise
Comini-Frota, Elizabeth
Coronetti Rocha, Fernando
Cruz dos Santos, Gutemberg Augusto
Dadalti Fragoso, Yara
Sciascia do Olival, Guilherme
Ruocco, Heloisa Helena
Siqueira, Heloise Helena
Sato, Henry Koity
Figueiredo, Jose Alexandre, Jr.
Cortoni Calia, Leandro
Teixeira Dourado, Mario Emilio, Jr.
Scolari, Leticia
Ribeiro Soares Neto, Herval
Melges, Luiz
Magno Goncalves, Marcus Vinicius
Vellutini Pimentel, Maria Lucia
de Castro Ribeiro, Marlise
Gurrola Arambula, Omar
Diniz da Gama, Paulo
Leite Menon, Renata
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2021, 8 (06):
[38] The effect of lowering dose of rituximab on the neuromyelitis optica spectrum disorder relapse rate during COVID-19 epidemic period
Mehdipour, Roshanak
Ashtari, Fereshteh
Asgari, Mina
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
[39] Clinical features of COVID-19 in patients with neuromyelitis optica spectrum disorders
Boaventura, M.
Apostolos-Pereira, S.
Ferreira, L.
Sousa, N.
Martins, G.
D'Almeida, J. A. C.
Pitombeira, M.
Mendes, L.
Fukuda, T.
Rocha, L.
Cabeca, H.
Oliveira, B.
Vieira Stella, C.
Oliveira, E. M.
Amorim, L.
Castro, A.
Gomes Neto, P.
Silva, G.
Bueno, L.
Machado, M.
Dias-Carneiro, R. P. C.
Dias, R.
Moreira, A.
Piccolo, A. C.
Grzesiuk, A.
Muniz, A.
Disserol, C.
Vasconcelos, C. C.
Diniz, D.
Kaimen-Maciel, D. L.
Comini-Frota, E.
Rocha, F.
Sciascia Do Olival, G.
Santos, G. A.
Ruocco, H. H.
Siqueira, H. H.
Sato, H.
Soares Neto, H.
Figueiredo, J., Jr.
Calia, L.
Scolari, L.
Melges, L. D.
Goncalves, M. V. M.
Pimentel, M. L.
Dourado Junior, M. E.
De Castro Ribeiro, M.
Arambula, O.
Gama, P. D.
Menon, R.
Thomaz, R.
MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (3_SUPPL) : 99 - 100
[40] The impact of the COVID-19 pandemic on hospitalizations and plasmapheresis therapy in multiple sclerosis and neuromyelitis optica spectrum disorder: a nationwide analysis from Germany
Richter, Daniel
Faissner, Simon
Bartig, Dirk
Toenges, Lars
Hellwig, Kerstin
Ayzenberg, Ilya
Krogias, Christos
Gold, Ralf
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2021, 14

← 1 2 3 4 5 →