Convalescent plasma in patients receiving rituximab or ocrelizumab for multiple sclerosis or neuromyelitis Optica spectrum disorder with Covid-19:A multicenter retrospective study

被引：0

作者：

Dequidt, Tanguy ^{[1
]}

Richier, Quentin ^{[2
]}

Louapre, Celine ^{[3
]}

Ader, Florence ^{[4
]}

Merad, Yanis ^{[4
]}

Lauwerier, Nicolas ^{[5
]}

Jacomet, Christine ^{[6
]}

Carles, Michel ^{[7
]}

Biron, Charlotte ^{[8
]}

Gendrin, Vincent ^{[9
]}

Marlat, Clement ^{[10
]}

Danion, Francois ^{[11
]}

Lepage, Tristan M. ^{[12
]}

Sotto, Albert ^{[13
]}

Bourdellon, Loic ^{[14
]}

Mania, Alexandre ^{[15
]}

Martinot, Martin ^{[16
]}

Le Falher, Georges ^{[17
]}

Ferre, Alexis ^{[18
]}

Pilmis, Benoit ^{[19
]}

Gondran, Guillaume ^{[20
]}

Simeone, Pierre ^{[21
]}

Henry, Matthieu ^{[22
]}

Kamel, Toufik ^{[23
]}

Ray, Simon ^{[24
]}

Ancellin, Sophie ^{[25
]}

Mele, Nicolas ^{[26
]}

Camou, Fabrice ^{[27
]}

Destremau, Marjolaine ^{[27
]}

Sellenet, Jeremy ^{[28
]}

Zucman, Noemie ^{[29
]}

Le Marechal, Marion ^{[30
]}

Mellouki, Khawla ^{[31
]}

Langlois, Marie-Elodie ^{[32
]}

Paz, David Luque ^{[33
]}

Mousset, Maud ^{[34
]}

Leclerc, Catherine ^{[35
]}

Sommet, Agnes ^{[36
]}

Lacombe, Karine ^{[37
]}

Martin-Blondel, Guillaume ^{[38
,39
]}

机构：

[1] Guadeloupe Univ Hosp, Dept Infect Dis, Pointe A Pitre, France

[2] Sorbonne Univ, St Antoine Hosp, Dept Infect Dis, AP HP, Paris, France

[3] Sorbonne Univ, Pitie Salpetriere Hosp, Paris Brain Inst, Dept Neurol,AP HP,CIC Neurosci, Paris, France

[4] Hosp Civils Lyon, Dept Infect Dis, Lyon, France

[5] Lille Univ Hosp, Dept Infect Dis, Lille, France

[6] Clermont Ferrand Univ Hosp, Dept Infect Dis, Clermont Ferrand, France

[7] Nice Univ Hosp, Dept Infect Dis, Nice, France

[8] Nantes Univ Hosp, Dept Infect Dis, Nantes, France

[9] Nord Franche Comte Hosp, Dept Infect Dis, Belfort, France

[10] Rouen Univ Hosp, Dept Infect Dis, Rouen, France

[11] Strasbourg Univ Hosp, Dept Infect Dis, Strasbourg, France

[12] Montpellier Univ Hosp, Dept Infect Dis, Montpellier, France

[13] Nimes Univ Hosp, Dept Infect Dis, Nimes, France

[14] Emile Durkheim Hosp, Med Unit A, Epinal, France

[15] Henri Mondor Hosp, Dept Internal Med, Aurillac, France

[16] Colmar Hosp, Dept Infect Dis, Colmar, France

[17] Beziers Hosp, Dept Internal Med, Beziers, France

[18] Versailles Hosp, Intens Care Unit, Le Chesnay, France

[19] Grp Hosp Paris St Joseph, Microbiol Unit, Antimicrobial Stewardship Team, Paris, France

[20] Limoges Univ Hosp, Dept Internal Med, Limoges, France

[21] Univ Hosp Timone, Dept Anesthesiol & Crit Care Med, AP HM, Marseille, France

[22] Dist Hosp Ctr, Med Surg Intens Care Unit, Le Roche Sur Yon, France

[23] Orleans Univ Hosp, Intens Care Unit, Orleans, France

[24] Rodez Hosp, Dept Infect Dis, Rodez, France

[25] Auch Hosp, Dept Infect Dis, Auch, France

[26] Sainte Anne Hosp, Dept Neurol, GHU Paris Psychiat & Neurosci, Paris, France

[27] Bordeaux Univ Hosp, Intens Care & Infect Dis Unit, Grp St Andre, Bordeaux, France

[28] St Jean Sud France Clin, Dept Internal Med, St Jean De Vedas, France

[29] CH Annecy Genevois, Intens Care Unit, Epagny Metz Tessy, France

[30] Univ Grenoble Alpes, Infect Dis Dept, CHU Grenoble Alpes, Grenoble, France

[31] Claude Bernard Univ Lyon 1, Valence Hosp Ctr, Dept Infect Dis, Valence, France

[32] St Joseph St Luc Hosp, Dept Internal Med & Infect Dis, Lyon, France

[33] Pontchaillou Univ Hosp, Infect Dis & Intens Care Unit, Rennes, France

[34] Comminges Pyrenees Hosp, Intens Care Unit, St Gaudens, France

[35] CHI Poissy St Germain En Laye, Dept Infect Dis, St Germain En Laye, France

[36] Toulouse Univ Hosp, Clin Invest Ctr, Toulouse, France

[37] Sorbonne Univ, St Antoine Hosp, Infect Dis Dept, IPLESP Inserm, Paris, France

[38] Toulouse Univ Hosp, Dept Infect Dis, Toulouse, France

[39] Toulouse III Univ, Toulouse Inst Infect & Inflammatory Dis, INSERM UMR1291 CNRS UMR5051, Toulouse, France

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2025年 / 151卷

关键词：

SARS-CoV-2; Protracted COVID-19; Convalescent plasma; Anti-CD20; antibodies; Multiple sclerosis; Neuromyelitis optica; THERAPY;

D O I：

10.1016/j.ijid.2024.107323

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Despite vaccination, patients receiving anti-CD20 monoclonal antibodies (mAbs) for multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD) have an increased risk of developing severe or protracted COVID-19. The aim of this study was to describe the effect of COVID-19 convalescent plasma (CCP) in patients with MS or NMOSD exposed to anti-CD20 and infected by SARS-CoV-2. Methods: This French national, retrospective cohort study was conducted between November 2020 and June 2023. Patients with MS or NMOSD, under anti-CD20 mAbs, with symptomatic COVID-19 and treated by CCP were screened. Protracted COVID-19 was defined by a duration of symptoms > 21 days. The primary endpoint was the overall survival 30 days after CCP administration. Results: Ninety-two patients from 34 hospitals were included, 84 (91%) with MS and 8 (9%) with NMOSD. Overall, 30-day survival was 97% (IC95%: 91-99). SARS-CoV-2 viremia was positive in 47/75 (61%) patients before CCP versus 9/59 (15%) seven days post-CCP. In the 52 patients (57%) with protracted COVID-19, the duration of symptoms before CCP was 51 [28-69] days, including fever in 75% of cases, which disappeared in 100% of patients 7 days post-CCP. Conclusions: CCP could be a therapeutic option in patients exposed to anti-CD20 mAbs for inflammatory demyelinating disease, particularly in those with protracted COVID-19. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

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页数：9

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