Electrochemical regioselective methylthiolation of imidazo[2,1-b]thiazoles with DMSO

被引：0

作者：

Xiao, Meng ^{[1
]}

Yi, Liyu ^{[1
]}

Liu, Wenjie ^{[1
,2
]}

Cao, Gao ^{[1
,2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou, Peoples R China

[2] Guangdong Cosmet Engn & Technol Res Ctr, Guangzhou, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2025年 / 55卷 / 04期

关键词：

DMSO; electrochemistry; imidazo[2; 1-b]thiazoles; methylthiolation; regioselectivity; DIMETHYL-SULFOXIDE; SULFUR; ACTIVATION; IMIDAZOPYRIDINES; THIOMETHYLATION; SULFENYLATION; DERIVATIVES; BENZAMIDES; AMINATION; ANTITUMOR;

D O I：

10.1080/00397911.2025.2453872

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With DMSO both as the source of -SMe unit and solvent, an efficient and green electrochemical methylthiolation reaction of imidazo[2,1-b]thiazoles was developed. The transformation was performed at room temperature in 8 h under external transition metal- and oxidant-free condition. Moreover, the 2,3-dihydroimidazo[2,1-b]thiazoles and 2-phenylbenzo[d]imidazo[2,1-b]thiazole also proceeded smoothly. This strategy provides C-5 methylthiolation products with broad scope in 73-91% yields.

引用

页码：338 / 349

页数：12

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