Improving Risk Stratification in pT3 Upper Tract Urothelial Carcinoma: A Focus on Invasion Patterns

被引：0

作者：

Chen, Yung-Tai ^{[1
,2
]}

Lee, Hsiang-Ying ^{[3
,4
,5
]}

Wu, Wen-Jeng ^{[3
,4
,5
]}

Lin, Chih-Hung ^{[6
,7
]}

Jiang, Yuan-Hong ^{[8
,9
]}

Lee, Yu-Khun ^{[8
,9
]}

Huang, Kuan-Hsun ^{[10
]}

Tsai, Yao-Chou ^{[11
,12
]}

机构：

[1] Taiwan Adventist Hosp, Dept Urol, Taipei 10556, Taiwan

[2] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Urol, Taipei 10051, Taiwan

[3] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 80756, Taiwan

[4] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Urol, Kaohsiung 80708, Taiwan

[5] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan

[6] Kaohsiung Municipal Hsiaokang Hosp, Dept Pathol, Kaohsiung 80756, Taiwan

[7] Kaohsiung Med Univ, Dept Pathol, Coll Med, Kaohsiung 80756, Taiwan

[8] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Urol, Hualien 97002, Taiwan

[9] Tzu Chi Univ, Hualien 97002, Taiwan

[10] Dalin Tzuchi Hosp, Buddhist Tzu Chi Med Fdn, Dept Chinese Med, Chiayi 62247, Taiwan

[11] Taipei Tzu Chi Hosp, Buddhist Med Fdn, Dept Surg, Div Urol, New Taipei City 23142, Taiwan

[12] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien 97004, Taiwan

来源：

CANCERS | 2025年 / 17卷 / 06期

关键词：

pathological stage; nephroureterectomy; upper urinary tract urothelial cancer; RADICAL NEPHROURETERECTOMY; ADJUVANT CHEMOTHERAPY; ONCOLOGICAL OUTCOMES; SUBCLASSIFICATION; CANCER; IMPACT;

D O I：

10.3390/cancers17060923

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Existing T3 subclassifications for upper tract urothelial cancer (UTUC) are limited by heterogeneity and a primary focus on renal pelvis tumors. Our study aimed to propose a novel pT3 subclassification system specifically tailored to pT3 UTUC patients. Materials and Methods: This study analyzed 120 pT3 UTUC cases from a Taiwanese multicenter registry, using a standardized pathology report and a single pathologist for evaluation. Results: Univariate analysis revealed survival differences based on existing subclassifications. Multivariate analysis identified concurrent fat and parenchyma invasion as an independent predictor of worse overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). Conclusions: This study proposes a novel pT3 subclassification incorporating fat and parenchyma invasion, applicable to all UTUC sites. This subclassification may improve risk stratification, guide treatment decisions, and ultimately enhance patient outcomes.

引用

页数：17

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