Programmed cell death receptor 1 inhibitor Pembrolizumab in the treatment of advanced gastric cancer

被引：0
|
作者：
Yi, Xue-Mei [1 ]
Cai, Hong-Qiao [2 ]
Jiao, Yan [2 ]
机构：
[1] Jilin Univ, Hosp 1, Dept Operat Room 2, Changchun 130021, Jilin, Peoples R China
[2] Jilin Univ, Hosp 1, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China
来源：
WORLD JOURNAL OF GASTROINTESTINAL SURGERY | 2025年 / 17卷 / 02期
关键词：
Programmed cell death receptor 1 inhibitor; Pembrolizumab; Advanced gastric cancer; Chemotherapy; Trastuzumab;
D O I：
10.4240/wjgs.v17.i2.100257
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This editorial discusses Christodoulidis et al's article, which appeared in the most recent edition. The clinical trials have demonstrated the programmed cell death receptor 1 (PD-1) inhibitor Pembrolizumab involved combination therapy can improve the efficacy of advanced gastric cancer (AGC). Pembrolizumab combined with chemotherapy can enhance its sensitivity, and further eliminate tumor cells that develop resistance to chemotherapy. The combination of Pembrolizumab and Trastuzumab targeting human epidermal growth factor receptor 2 showed improved prognosis. The overall toxic effects of Pembrolizumab are significantly lower than traditional chemotherapy, and the safety is controllable. PD-1 inhibitor Pembrolizumab sheds a light on the treatment of AGC and brings new hope to the clinical practice.
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页数：5
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