Fertility and abortion: A population-based comparison between women with cancer and those in childbearing age

被引：0

作者：

Maraschini, Alice ^{[1
]}

Decenti, Edoardo Corsi ^{[2
]}

Donati, Serena ^{[2
]}

Francisci, Silvia ^{[2
]}

Lopez, Tania ^{[2
]}

Amodio, Rosalba ^{[3
]}

Bianconi, Fortunato ^{[4
]}

Bovo, Emanuela ^{[5
]}

Bruni, Rossella ^{[6
]}

Castaing, Marine ^{[7
]}

Cirilli, Claudia ^{[8
]}

De Vincenzo, Rosa Pasqualina ^{[9
]}

Furgiuele, Giuseppe ^{[10
]}

Guarda, Linda ^{[11
]}

Iacovacci, Silvia ^{[12
]}

Mangone, Lucia ^{[13
]}

Mazzucco, Walter ^{[3
]}

Melcarne, Anna ^{[14
]}

Merlo, Elisabetta ^{[15
]}

Mian, Michael ^{[16
]}

Sampietro, Giuseppe ^{[17
]}

Scambia, Giovanni ^{[9
]}

Scuderi, Tiziana ^{[18
]}

Sferrazza, Ausilia ^{[19
]}

Stracci, Fabrizio ^{[20
]}

Torrisi, Antonina ^{[21
]}

Trojano, Vito ^{[22
]}

Vitale, Maria Francesca ^{[23
]}

Pierannunzio, Daniela ^{[2
]}

机构：

[1] Italian Natl Inst Hlth, Tech Sci Stat Serv, Rome, Italy

[2] Italian Natl Inst Hlth, Natl Ctr Dis Prevent & Hlth Promot, Rome, Italy

[3] Azienda Osped Univa Policlin P Giaccone AOUP, Clin Epidemiol & Canc Registry Unit, Palermo, Italy

[4] Area Operativa ICT PuntoZero Scarl, Perugia, Italy

[5] Serv Epidemiol Regionale, Registro Tumori Veneto, Azienda Zero, Padua, Italy

[6] AReSS Puglia, Agenzia Reg Salute & Sociale, Bari, Italy

[7] Siracusa Canc Registry, Hlth Unit Siracusa, Siracusa, Italy

[8] AUSL Modena, Dipartimento Epidemiol & Comunicaz Rischio, I-41012 Modena, Italy

[9] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[10] ASP Catanzaro, Catanzaro, Italy

[11] ATS Valpadana, SC Osservatorio Epidemiol, Mantua, Italy

[12] UOC Epidemiol, ASL Latina, Latina, Italy

[13] AUSL IRCCS Reggio Emilia, Gynecol Oncol Dept, European Epidemiol Unit, Reggio Emilia, Italy

[14] Registro Tumori ASL Lecce, I-73100 Lecce, Italy

[15] UOC Epidemiol, Agenzia Tutela Salute ATS Brianza, I-20900 Monza, Italy

[16] Paracelsus Med Private Univ PMU, Innovat Res & Teaching Serv SABES ASDAA, Innovat Res & Teaching Serv, Bolzano, Italy

[17] Hlth Protect Agcy Bergamo ATS Bergamo, Bergamo, Italy

[18] UOSD Registro Tumori, ASP Trapani, Dipartimento Prevenz, I-91100 Trapani, Italy

[19] UOSD Registro Tumori, ASP Ragusa Dipartimento Med Prevenz, I-97100 Ragusa, Italy

[20] Univ Perugia, Dept Med & Surg, Sect Publ Hlth, Perugia, Italy

[21] Azienda Osped Univ Policlin G Rodolico San Marco, Registro Tumori Integrato, Catania, Italy

[22] Italian Soc Gynaecol & Obstet, Rome, Italy

[23] Napoli 3 Sud Canc Registry, Brusciano, Italy

来源：

TUMORI JOURNAL | 2025年 / 111卷 / 01期

关键词：

Cancer; pregnancy outcome; induced abortion; miscarriage; delivery; fertility; population-based data; cancer registry records; hospital discharge data; relative risk; PREGNANCY-ASSOCIATED CANCER; PROBABILITY; PARENTHOOD; DIAGNOSIS; OUTCOMES; DENMARK; COHORT; ONSET; RISK;

D O I：

10.1177/03008916241298810

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Concurrence of pregnancy and cancer diagnosis is increasingly frequent in Italy. The study aimed to compare women with pregnancy-associated cancers (PACs) to those of childbearing age, focusing on fertility, induced abortion, and miscarriage.Methods: The population-based study included women aged 15-49 years, both with and without PAC, who were residents in the area covered by the 19 participating Cancer Registries between 2003 and 2015 and identified by individual deterministic linkage with the Hospital Discharge Database.Results: Overall, 2,218,139 obstetrics hospitalizations occurred, covering delivery (75%), induced abortion (14%), and miscarriage (11%). Among 2409 women with PAC, 69% gave birth, 16% had an induced abortion and 15% a miscarriage. Compared with the reference population, the fertility rate in women with PACs was steadily lower (mean values 25.7/1000 vs 37.7/1000), while induced abortion (from 359/1000 - SRR 1.99, 95%CI 1.32-3.00 - in 2003 to 147/1000 - SRR 1.11, 95%CI 0.59-2.09 - in 2015) and miscarriage ratios exhibited a decreasing trend.Conclusion: These results are consistent with international literature and are probably due to advancements in diagnostic and therapeutic opportunities. This is the first Italian population-based study analysing fertility and pregnancy outcomes among women with PAC based on a reliable information on cancer diagnosis.

引用

页码：71 / 78

页数：8

共 50 条

[41] RELATIONSHIP BETWEEN AGE AT MENARCHE AND AGE AT MARRIAGE AMONG CHILDBEARING WOMEN
BUCK, C
STAVRAKY, K
HUMAN BIOLOGY, 1967, 39 (02) : 93 - &
[42] Seroepidemiology of TORCH Infections among 1.7 Million Women of Childbearing Age in Rural China: A Population-Based Cross-Sectional Study
Qin, Xiaosong
Zhang, Shikun
Liu, Hongbo
Cheng, Guixue
Liu, Yong
Hu, Mei
Liu, Na
Zhang, Man
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2021, 105 (05): : 1202 - 1209
[43] Childbearing and Salivary Gland Cancer A Population-based Nested Case-control Study
Lu, Yunxia
Lagergren, Jesper
Eloranta, Sandra
Lambe, Mats
EPIDEMIOLOGY, 2009, 20 (05) : 780 - 782
[44] Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
Chung, Min Kyung
Lee, Chan Hee
Park, Jin Su
Lim, Hyunsun
Lee, Jisoo
KOREAN JOURNAL OF INTERNAL MEDICINE, 2022, 37 (06): : 1250 - 1259
[45] Age and distress of women–results of a representative population-based study
Jutta Lindert
Jaqueline Müller-Nordhorn
Joaquim F. Soares
Archives of Women's Mental Health, 2009, 12
[46] COMORBIDITIES AMONG KOREAN WOMEN WITH RHEUMATOID ARTHRITIS IN CHILDBEARING YEARS: A NATIONWIDE POPULATION-BASED STUDY
Chung, M. K.
Lim, H. S.
Park, J. S.
Lee, C. H.
Lee, J.
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 281 - 282
[47] General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women
MacBeth, Angus
McSkimming, Paula
Bhattacharya, Sohinee
Park, John
Gumley, Andrew
St Clair, David
Barry, Sarah J. E.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, 2023, 58 (01) : 105 - 112
[48] General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women
Angus MacBeth
Paula McSkimming
Sohinee Bhattacharya
John Park
Andrew Gumley
David St Clair
Sarah J. E. Barry
Social Psychiatry and Psychiatric Epidemiology, 2023, 58 : 105 - 112
[49] Cervical cancer in women under 30 years of age in Norway: a population-based cohort study
Brit Helene Gravdal
Stefan Lönnberg
Gry Baadstrand Skare
Gerhard Sulo
Tone Bjørge
BMC Women's Health, 21
[50] Cervical cancer in women under 30 years of age in Norway: a population-based cohort study
Gravdal, Brit Helene
Loennberg, Stefan
Skare, Gry Baadstrand
Sulo, Gerhard
Bjorge, Tone
BMC WOMENS HEALTH, 2021, 21 (01)

← 1 2 3 4 5 →