Preparation, Coating, and Multimodal Therapeutic Properties of an Anticancer System Based on UiO-66(Ce)

被引：0
|
作者：
Hu, Quan [1 ]
Lei, Chen [3 ]
Sun, Yue [3 ]
Hong, Lu [3 ]
Shi, Yu [3 ]
Sang, Liyuan [3 ]
Wang, Bing [3 ]
Guo, Yong [1 ,2 ]
Lin, Wenxin [3 ]
机构：
[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Zhejiang, Peoples R China
[2] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejiang, Key Lab Elemene Class Anticanc Chinese Med, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou 311121, Zhejiang, Peoples R China
[3] Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Hangzhou 310018, Zhejiang, Peoples R China
来源：
INORGANIC CHEMISTRY | 2025年 / 64卷 / 06期
基金：
中国国家自然科学基金;
关键词：
METAL-ORGANIC FRAMEWORKS; CANCER;
D O I：
10.1021/acs.inorgchem.4c04783
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
UiO-66(Ce) was prepared from cerium metal, which could trigger Fenton-like reactions. A system DOX@UiO-66(Ce)@TA-Fe was constructed by coating a metal polyphenol layer (TA-Fe) on the surface of DOX@UiO-66(Ce), which was loaded with the anticancer drug doxorubicin hydrochloride (DOX). It could produce reactive oxygen species to realize chemodynamic therapy and show stimuli-responsive drug release behaviors to realize chemotherapy. In addition, the system displayed biocompatibility to normal cells (L929 cells) and toxicity to cancer cells (MCF-7 cells), implying an ideal effect for multimodal cancer therapy.
引用
收藏
页码：2809 / 2814
页数：6
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