Preparation, Coating, and Multimodal Therapeutic Properties of an Anticancer System Based on UiO-66(Ce)

被引：0

作者：

Hu, Quan ^{[1
]}

Lei, Chen ^{[3
]}

Sun, Yue ^{[3
]}

Hong, Lu ^{[3
]}

Shi, Yu ^{[3
]}

Sang, Liyuan ^{[3
]}

Wang, Bing ^{[3
]}

Guo, Yong ^{[1
,2
]}

Lin, Wenxin ^{[3
]}

机构：

[1] Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Zhejiang, Peoples R China

[2] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejiang, Key Lab Elemene Class Anticanc Chinese Med, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou 311121, Zhejiang, Peoples R China

[3] Zhejiang Sci Tech Univ, Sch Mat Sci & Engn, Hangzhou 310018, Zhejiang, Peoples R China

来源：

INORGANIC CHEMISTRY | 2025年 / 64卷 / 06期

基金：

中国国家自然科学基金;

关键词：

METAL-ORGANIC FRAMEWORKS; CANCER;

D O I：

10.1021/acs.inorgchem.4c04783

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

UiO-66(Ce) was prepared from cerium metal, which could trigger Fenton-like reactions. A system DOX@UiO-66(Ce)@TA-Fe was constructed by coating a metal polyphenol layer (TA-Fe) on the surface of DOX@UiO-66(Ce), which was loaded with the anticancer drug doxorubicin hydrochloride (DOX). It could produce reactive oxygen species to realize chemodynamic therapy and show stimuli-responsive drug release behaviors to realize chemotherapy. In addition, the system displayed biocompatibility to normal cells (L929 cells) and toxicity to cancer cells (MCF-7 cells), implying an ideal effect for multimodal cancer therapy.

引用

页码：2809 / 2814

页数：6

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