Perineural invasion and laryngeal squamous cell carcinoma: a systematic review

Objectives: Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer. Methods: A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis. Results: A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59-0.86); disease-free survival RR 0.51 (0.14-1.95); and locoregional recurrence RR 1.71 (1.25-2.35). Conclusion: IPN is a negative prognostic factor in laryngeal cancer. (c) 2024 Published by Elsevier Espana, S.L.U. on behalf of Associac,ao Brasileira de Otorrinolaringologia e Cirurgia Ce<acute accent>rvico-Facial. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).