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Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery
被引:0
|作者:
Erickson, Nicholas J.
[1
]
Stavarache, Mihaela
[2
]
Tekedereli, Ibrahim
[1
]
Kaplitt, Michael G.
[2
]
Markert, James M.
[1
]
机构:
[1] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL 35294 USA
[2] Weill Cornell Med, Dept Neurol Surg, Lab Mol Neurosurg, New York, NY USA
关键词:
Magnetic resonance-guided focused ultrasound;
Magnetic Malignant glioma;
Oncolytic viral therapy;
INTENSITY FOCUSED ULTRASOUND;
BRAIN-BARRIER DISRUPTION;
LIPOSOMAL DOXORUBICIN;
RIBONUCLEOTIDE REDUCTASE;
GLIOBLASTOMA-MULTIFORME;
ENHANCED DELIVERY;
TUMOR BARRIER;
VIRUS;
REPLICATION;
VIROTHERAPY;
D O I:
10.1016/j.wneu.2024.123595
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner.
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页数:9
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