Fine-tuning of proteasome inhibitors through rational pathway engineering

被引：0
|
作者：
Baunach, Martin [1 ]
机构：
[1] Univ Bonn, Inst Pharmaceut Biol, Nussallee 6, D-53115 Bonn, Germany
来源：
CHEM | 2024年 / 10卷 / 10期
关键词：
D O I：
10.1016/j.chempr.2024.09.019
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The production of tailored biological drugs by genetic engineeringrepresents a significant challenge in the field of natural productchemistry. In this issue ofChem, Bode and co-workers have success-fully developed a biosynthetic production platform for novel syrbac-tin-class proteasome inhibitorsby assembling an NRPS/PKS hybridfrom four different natural megasynthetases.
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