Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia

被引：0
|
作者：
Lin, Shan [1 ,2 ,3 ]
Kotliar, Michael [4 ]
Vallabh, Sushmitha [4 ]
Ptasinska, Anetta [2 ,5 ]
Assi, Salam A. [2 ,5 ]
Wunderlich, Mark [1 ]
Bonifer, Constanze [2 ,5 ]
Barski, Artem [4 ,6 ,7 ]
Mulloy, James C. [1 ,7 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH USA
[2] Seattle Childrens Res Inst, Ben Towne Ctr Childhood Canc & Blood Disorders Res, Seattle, WA USA
[3] Univ Washington, Dept Pediat, Seattle, WA USA
[4] Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol, Cincinnati, OH USA
[5] Univ Birmingham, Inst Canc & Genom Sci, Coll Med & Dent, Birmingham, England
[6] Cincinnati Childrens Hosp Med Ctr, Div Human Genet, Cincinnati, OH USA
[7] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA
来源：
BLOOD ADVANCES | 2025年 / 9卷 / 04期
基金：
美国国家卫生研究院;
关键词：
GENE-EXPRESSION; DISTINCT; MLL-AF4; INHIBITION; RESISTANCE; LANDSCAPE;
D O I：
10.1182/bloodadvances.2024014065
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：856 / 861
页数：6
相关论文
共 50 条
  • [21] Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale
    Stumpel, D. J. P. M.
    Schotte, D.
    Lange-Turenhout, E. A. M.
    Schneider, P.
    Seslija, L.
    de Menezes, R. X.
    Marquez, V. E.
    Pieters, R.
    den Boer, M. L.
    Stam, R. W.
    LEUKEMIA, 2011, 25 (03) : 429 - 439
  • [22] Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale
    D J P M Stumpel
    D Schotte
    E A M Lange-Turenhout
    P Schneider
    L Seslija
    R X de Menezes
    V E Marquez
    R Pieters
    M L den Boer
    R W Stam
    Leukemia, 2011, 25 : 429 - 439
  • [23] A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
    Krivtsov, Andrei V.
    Evans, Kathryn
    Gadrey, Jayant Y.
    Eschle, Benjamin K.
    Hatton, Charlie
    Uckelmann, Hannah J.
    Ross, Kenneth N.
    Perner, Florian
    Olsen, Sarah N.
    Pritchard, Tara
    McDermott, Lisa
    Jones, Connor D.
    Jing, Duohui
    Braytee, Ali
    Chacon, Diego
    Earley, Eric
    McKeever, Brian M.
    Claremon, David
    Gifford, Andrew J.
    Lee, Heather J.
    Teicher, Beverly A.
    Pimanda, John E.
    Beck, Dominik
    Perry, Jennifer A.
    Smith, Malcolm A.
    McGeehan, Gerard M.
    Lock, Richard B.
    Armstrong, Scott A.
    CANCER CELL, 2019, 36 (06) : 660 - +
  • [24] The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia
    Stumpel, Dominique J. P. M.
    Schneider, Pauline
    Pieters, Rob
    Stam, Ronald W.
    EUROPEAN JOURNAL OF CANCER, 2015, 51 (14) : 2008 - 2021
  • [25] Prognosis of Children with MLL-rearranged Acute Myeloid Leukemia
    Yamamori, Ayako
    Maemura, Ryo
    Wakamatsu, Manabu
    Sakaguchi, Hirotoshi
    Yoshida, Nao
    Kato, Koji
    PEDIATRIC BLOOD & CANCER, 2017, 64 : S72 - S72
  • [26] Targeting chromatin potently inhibits leukemia progression in MLL-rearranged leukemia models
    Xiao, Lin
    Karsa, Mawar
    Ronca, Emma
    Bongers, Angelika
    Gao, Weiman
    Kosciolek, Angelika
    El-Ayoubi, Ali
    Norris, Murray
    Haber, Michelle
    Somers, Klaartje
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2021, 17 : 15 - 15
  • [27] MLL Gene Rearranged Acute Lymphoblastic Leukemia
    Pieters, Rob
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2018, 18 : S48 - S50
  • [28] NF-κB activation mediates resistance to IFNβ in MLL-rearranged acute lymphoblastic leukemia
    L Tracey
    C J Streck
    Z Du
    R F Williams
    L M Pfeffer
    A C Nathwani
    A M Davidoff
    Leukemia, 2010, 24 : 806 - 812
  • [29] Bet Inhibition as a Novel Therapeutic Approach for the Treatment of MLL-Rearranged Acute Lymphoblastic Leukemia in Infants
    Bardini, M.
    Trentin, L.
    Rizzo, F.
    Vieri, M.
    Savino, A. M.
    Fazio, G.
    Geertruy, T. K.
    Basso, G.
    Cazzaniga, G.
    Biondi, A.
    PEDIATRIC BLOOD & CANCER, 2016, 63 : S101 - S101
  • [30] PREDICTION OF OUTCOME IN INFANTS WITH MLL-REARRANGED ACUTE LYMPHOBLASTIC LEUKEMIA BY TIME TO ACHIEVEMENT OF MOLECULAR REMISSION
    Tsaur, Grigory
    Nasedkina, Tatyana
    Ivanova, Anna
    Yakovleva, Yulia
    Riger, Tatyana
    Popov, Alexander
    Shorikov, Egor
    Saveliev, Leonid
    Fechina, Larisa
    PEDIATRIC BLOOD & CANCER, 2009, 53 (05) : 777 - 777
12345