Evaluating the Genotoxicity of Small-Molecule Nitrosamines and Nitrosamine Drug Substance-Related Impurities in 2D and 3D HepaRG Cell Models

被引:0
|
作者
Xu, Hannah [1 ]
Seo, Ji-Eun [1 ]
Li, Xilin [1 ]
Mei, Nan [1 ]
Heflich, Robert [1 ]
Atrakchi, Aisar H. [2 ]
McGovern, Timothy J. [2 ]
Bruno, Karen L. Davis [2 ]
Guo, Xiaoqing [1 ]
机构
[1] US FDA, Div Genet & Mol Toxicol, Natl Ctr Toxicol Res, Jefferson, AR USA
[2] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD USA
关键词
D O I
暂无
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
PS100
引用
收藏
页码:109 / 110
页数:2
相关论文
共 50 条
  • [11] Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
    Seo, Ji-Eun
    Le, Yuan
    Revollo, Javier
    Miranda-Colon, Jaime
    Xu, Hannah
    McKinzie, Page
    Mei, Nan
    Chen, Tao
    Heflich, Robert H.
    Zhou, Tong
    Robison, Timothy
    Bonzo, Jessica A.
    Guo, Xiaoqing
    ARCHIVES OF TOXICOLOGY, 2024, 98 (06) : 1919 - 1935
  • [12] Approximation of 2D and 3D models of chemotactic cell movement in vasculogenesis
    Cavalli, Fausto
    Gamba, Andrea
    Naldi, Giovanni
    Semplice, Matteo
    MATH EVERYWHERE: DETERMINISTIC AND STOCHASTIC MODELLING IN BIOMEDICINE, ECONOMICS AND INDUSTRY, 2007, : 179 - +
  • [13] Generation of Fully Functional 2D and 3D Human Small Airway Models
    Kramer, P.
    Brown, T.
    Tellis, M.
    Rowbotham, D.
    Hou, J.
    Eaves, A. C.
    Louis, S.
    Chang, W.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [14] Genotoxicity of quinolones: Substituents contribution and transformation products QSAR evaluation Using 2D and 3D models
    Li, Min
    Wei, Dongbin
    Zhao, Huimin
    Du, Yuguo
    CHEMOSPHERE, 2014, 95 : 220 - 226
  • [15] Small-molecule labeling of live cell surfaces for 3D super-resolution microscopy
    Lee, Marissa K.
    Rai, Prabin
    Williams, Jarrod
    Twieg, Robert J.
    Moerner, W. E.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [16] Comparative Assay of 2D and 3D Cell Culture Models: Proliferation, Gene Expression and Anticancer Drug Response
    Souza, Aline G.
    Silva, Isaura Beatriz B.
    Campos-Fernandez, Esther
    Barcelos, Leticia S.
    Souza, Jessica Brito
    Marangoni, Karina
    Goulart, Luiz R.
    Alonso-Goulart, Vivian
    CURRENT PHARMACEUTICAL DESIGN, 2018, 24 (15) : 1689 - 1694
  • [17] 2D and 3D human endothelial cell models to assess vascular toxicity
    Fischer, B.
    Burger, A.
    Moretti, F.
    TOXICOLOGY LETTERS, 2022, 368 : S284 - S284
  • [18] Lipidomic comparison of 2D and 3D colon cancer cell culture models
    Tobias, Fernando
    Hummon, Amanda B.
    JOURNAL OF MASS SPECTROMETRY, 2022, 57 (08):
  • [19] Type of endothelial cells affects HepaRG cell acetaminophen metabolism in both 2D and 3D porous scaffold cultures
    German, Carrie L.
    Madihally, Sundararajan V.
    JOURNAL OF APPLIED TOXICOLOGY, 2019, 39 (03) : 461 - 472
  • [20] Novel 2D and 3D cell systems for prediction of acute and chronic drug toxicity
    Ingelman-Sundberg, Magnus
    TOXICOLOGY LETTERS, 2014, 229 : S38 - S38