Prognostic value of Ki-67 in patients with ovarian cancer

被引：0
|
作者：
Wan, Su [1 ,2 ]
Su, Chang [1 ]
Wang, Yong [3 ]
Ding, Jin [1 ]
Jiang, Qingya [1 ]
Ding, Huafeng [1 ]
Ni, Guantai [1 ]
机构：
[1] Wannan Med Coll, Affiliated Hosp 1, Dept Obstet & Gynecol, Wuhu 241000, Anhui, Peoples R China
[2] Soochow Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Suzhou 215000, Jiangsu, Peoples R China
[3] Wannan Med Coll, Affiliated Hosp 2, Dept Obstet & Gynecol, Wuhu 241000, Anhui, Peoples R China
来源：
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2025年 / 46卷 / 01期
关键词：
Ki-67; Ovarian cancer; Survival; Prognosis; EXPRESSION; KI67;
D O I：
10.22514/ejgo.2023.051
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The present work focused on investigating if Ki-67 antigen (Ki-67) could be used to predict prognosis of epithelial ovarian cancer (EOC). Methods: This study retrospectively identified 78 consecutive epithelial ovarian cancer cases who underwent surgery at the First Affiliated Hospital of Wannan Medical College between January 2014 and April 2017. The association between Ki-67 expression and clinicopathological characteristics and survival was analyzed. Results: High Ki-67 expression was significantly associated with high stage, high histological grade, ascites, and high level of cancer antigen 125 (CA125) (p = 0.011, p = 0.031, p = 0.033, p = 0.004, respectively). In addition, high Ki-67 expression was significantly associated with poor prognosis (p = 0.002), which was further confirmed using a multivariate Cox regression hazards model (Hazard Ratio (HR) = 1.797, 95% confidence interval (CI) = 1.038-3.111, p = 0.026). Conclusions: Ki-67 expression may be a significant prognostic factor in epithelial ovarian cancer.
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收藏
页码：76 / 81
页数：6
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