Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer

被引：0

作者：

Shen, Qi ^{[1
]}

Zhou, Kaichen ^{[1
]}

Lu, Haosen ^{[2
]}

Zhang, Jielin ^{[1
]}

Xu, Qiqing ^{[1
]}

Zhang, Chengsi ^{[1
]}

Yang, Chunhua ^{[1
]}

Mao, Lijun ^{[2
]}

机构：

[1] Xuzhou Med Univ, Jiangsu Key Lab Biol Canc Therapy, Xuzhou 221002, Peoples R China

[2] Xuzhou Med Univ, Affiliated Hosp, Dept Radiotherapy, Xuzhou 221000, Peoples R China

来源：

DISCOVER ONCOLOGY | 2024年 / 15卷 / 01期

关键词：

B7-H3; CD276; B7; family; Prostate cancer; Immune checkpoint; CELLS;

D O I：

10.1007/s12672-024-01674-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic target. Both coinhibitory and costimulatory effects of B7-H3 in tumors have been demonstrated, but the mechanism of B7-H3 immune response under dual effects is open to question. B7-H3 is crucially involved in the migration and invasion, angiogenesis, metabolism and chemotherapy resistance of prostate cancer. In addition to the potential immune effects on tumor environment, B7-H3 plays a non-immune-mediated role in tumor progression. In this review, we summarize current understanding of molecular mechanism of B7-H3 in prostate cancer and discuss the potential of B7-H3 as a novel therapeutic target for prostate cancer.

引用

页数：12

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