Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer

被引：0
|
作者：
Shen, Qi [1 ]
Zhou, Kaichen [1 ]
Lu, Haosen [2 ]
Zhang, Jielin [1 ]
Xu, Qiqing [1 ]
Zhang, Chengsi [1 ]
Yang, Chunhua [1 ]
Mao, Lijun [2 ]
机构：
[1] Xuzhou Med Univ, Jiangsu Key Lab Biol Canc Therapy, Xuzhou 221002, Peoples R China
[2] Xuzhou Med Univ, Affiliated Hosp, Dept Radiotherapy, Xuzhou 221000, Peoples R China
来源：
DISCOVER ONCOLOGY | 2024年 / 15卷 / 01期
关键词：
B7-H3; CD276; B7; family; Prostate cancer; Immune checkpoint; CELLS;
D O I：
10.1007/s12672-024-01674-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic target. Both coinhibitory and costimulatory effects of B7-H3 in tumors have been demonstrated, but the mechanism of B7-H3 immune response under dual effects is open to question. B7-H3 is crucially involved in the migration and invasion, angiogenesis, metabolism and chemotherapy resistance of prostate cancer. In addition to the potential immune effects on tumor environment, B7-H3 plays a non-immune-mediated role in tumor progression. In this review, we summarize current understanding of molecular mechanism of B7-H3 in prostate cancer and discuss the potential of B7-H3 as a novel therapeutic target for prostate cancer.
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页数：12
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