Advances in engineered bacteria vaccines for enhancing anti-cancer immunity

被引：1
|
作者：
Liu, Wu [1 ]
Chen, Wenjing [2 ]
Cai, Yujie [2 ]
Tang, Yanhua [3 ]
Chen, Tingtao [1 ,4 ,5 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Nanchang 330008, Jiangxi, Peoples R China
[2] Nanchang Univ, Jiangxi Med Coll, Sch Pharm, Nanchang 330008, Jiangxi, Peoples R China
[3] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Cardiovasc Surg, 1 Minde Rd, Nanchang 330008, Jiangxi, Peoples R China
[4] Nanchang Univ, Jiangxi Med Coll, MOE Basic Res & Innovat Ctr Targeted Therapeut Sol, Sch Pharm,Jiangxi Prov Key Lab Bioengn Drugs, Nanchang 330031, Jiangxi, Peoples R China
[5] Nanchang Univ, Inst Translat Med, Jiangxi Med Coll, Natl Engn Res Ctr Bioengn Drugs & Technol, 1299 Xuefu Ave, Nanchang 330031, Jiangxi, Peoples R China
来源：
MICROBIOME RESEARCH REPORTS | 2025年 / 4卷 / 01期
关键词：
Engineered bacteria; antitumor; neoantigenic; immunotherapy;
D O I：
10.20517/mrr.2024.75
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Advances in synthetic biology have enabled the development of tumor-targeted live bacterial therapeutics. In a recent study published in Nature, Redenti et al. engineered Escherichia coli Nissle 1917(EcNc Delta lon/Delta ompT/LLO+ nAg), which exploits the advantages of living medicines to deliver arrays of tumor-specific neoantigenic epitope in optimal environments, thereby providing a novel strategy for developing effective and durable cancer immunotherapies.
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页数：4
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